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甲胎蛋白在不同发育时期的大鼠胃组织中的表达及定位

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摘要 目的:研究大鼠正常发育的各个阶段胃组织中甲胎蛋白(AFP)的表达情况及定位。方法:提取大鼠胚胎发育18.5天(e18.5d),e20.5d,新生大鼠(p0d),p7d,p14d,p21d以及成年大鼠的胃组织。检测各时期AFP的蛋白与AFP mRNA的表达以及在胃组织中的定位。结果:AFP在e18.5d大鼠的胃组织中蛋白和mRNA表达量均显著高于其他各时期,出生后表达量稳步下降,成年后消失;AFP在大鼠的胃组织中与间充质细胞标志物波形蛋白(vimentin)呈共表达。结论:AFP在发育的各个时期均特异性表达在大鼠胃间充质细胞,可能对胃结构的形成和功能的完善起着重要作用。
作者 苏兰娣
机构地区 江苏省扬州环境资源职业技术学院医学系
出处 《中外妇儿健康（学术版）》 2011年第6期89-90,共2页
关键词 AFP 发育 间充质细胞 胃 大鼠
分类号 R574 [医药卫生—消化系统]
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参考文献8

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中外妇儿健康（学术版）
2011年 第6期

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