白细胞介素17、高敏C反应蛋白、白细胞计数联合检测在急性心肌梗死中的意义

Significance of the combination detection of IL-17,WBC count and Hs-CRP in patients with acute myocardial infarction

目的观察白细胞介素17(IL-17)、高敏C反应蛋白(hs-CRP)、白细胞计数(WBC)在急性心肌梗死(AMI)患者血清中的水平变化及相关性,了解IL-17与AMI发病的关系。方法 95例患者分为3组:急性心肌梗死(AMI)40例,不稳定型心绞痛(UA)31例,胸痛综合征(CPS)24例。患者入院后立即留取静脉血标本离心,存于-80℃的冰箱,采用ELISA法集中检测患者血清中的IL-17、hs-CRP水平,并急诊送检白细胞计数水平。结果 AMI组外周血清IL-17水平明显高于UA组和CPS组(P<0.01);AMI组患者hs-CRP水平明显高于UA组和CPS组(P<0.05);AMI组患者WBC明显高于UA组和CPS组(P<0.01);相关性分析提示IL-17与hs-CRP(r=0.364,P<0.01)及WBC水平(r=0.302,P=0.004)均呈正相关。结论在AMI患者血清中IL-17水平明显升高,与hs-CRP、WBC呈正相关,推测IL-17与动脉粥样硬化斑块不稳定性有关,促进了AMI的发生发展。

Objective To investigate the serum IL-17 ,Hs-CRP and white blood cell（ WBC）count in patients with acute myocardial infarction（ AMI）, and to explore the relationship between IL-17 and inflammatory factors in patients with AMI. Methods 95 patients were divided into 3 groups ： acute myocardial infarction （AMI） in 40 cases, angina（ UA）31 cases,patients with chest pain syndrome（ CPS）24 cases. Specimens were collected immediately after admission, and stored at-80℃ in the refrigerator,then the IL-17 and hs-CRP levels were detected by ELISA. Results The serum IL-17 level in AMI group was higher than theUA and CPS group （P 〈 0.01 ） , the serum Hs-CRP level of AMI was higher than the those other two groups （ P 〈 0.05 ）, and the WBC levels was higher in UA and CPS group （P 〈 0.01 ）;The correlation analysis showed that the IL-17 was positively correlated with hs-CRP（ r = 0. 364, P 〈 0.01 ） and WBC （ r = 0. 302, P = 0. 004）. Conclusion Among AMI patients, the serum IL-17 level was significantly increased,and positively correlated with hs-CRP and WBC levels, IL-17 might be involved in the pathogenesis of AMl,and promote processes at early stage of AMI.