抗线粒体抗体M2在原发性干燥综合征中的阳性率及临床意义

Significance of M2 autoantibody detection in primary Sjgren's syndrome

目的探讨抗线粒体抗体M2在原发性干燥综合征中的阳性率及其临床意义。方法 158例原发性干燥综合征患者,收集患者一般资料,自身抗体、r球蛋白、肝功能、肝活检情况并采用酶联免疫吸附方法检测抗线粒体抗体M2。结果 158例患者,抗线粒体抗体M2阳性41例(25.9%),其中强阳性15例(9.5%),弱阳性26例(16.5%)。肝功能异常40例(25.3%)。共确诊原发性胆汁性肝硬化17例(10.8%)。结论抗线粒体抗体M2在原发性干燥综合征患者中阳性率较高,强阳性对诊断原发性胆汁性肝硬化有重要意义,对弱阳性患者需要长期随诊观察。

Objective To study the significance of M2 autoantibody detection in patients with primary Sjogren＇ s syndrome（pSS）. MethodsThe clinical data of 158 patients with primary SS were collected and retrospectively investigated. M2 antibody was tested by enzyme-linked immuno sorbent assay（ELISA） method. Results M2 anti- body was detected in 41 （ 25.9% ） of the patients. Of them, 15 （9.5%） had strongly positive staining,26 （ 16.5% ） had weak staining. 40（25.3% ）of the patients had cholestatic liver biochemistry. The results showed that 17（ 10.8% ）of the patients had primary biliary cirrhosis （PBC）. Conclusion M2 antibody detection is often positive in patients with primary SS. Strong positivity of M2 antibody is very helpful to the diagnosis of PBC.