丹红注射液联合常规疗法用于慢性呼吸衰竭急性加重期的临床观察

Clinical observation on treatment of acute exacerbation of chronic respiratory failure with conventional western medicine therapy combined with Danhong injection

目的观察丹红注射液联合西医常规疗法治疗慢性呼吸衰竭急性加重期的临床疗效。方法按随机数字表法将64例慢性呼吸衰竭急性加重期患者随机分为两组各32例。对照组采用常规对症治疗（包括吸氧、抗感染、解痉平喘、化痰等），治疗组在对照治疗基础上加用丹红注射液30ml，加入5％葡萄糖注射液250ml静脉滴注，1次／d，两组均治疗14d为1个疗程。结果治疗组总有效率为87．50％，对照组为65．63％，两组总有效率比较，差异有统计学意义（x^2=4．267，P〈O．05）。治疗组治疗后全血低切黏度（7．11±1．60）mPa·s、全血高切黏度（3．30±0．83）mPa·s、血浆黏度（1．28±0．32）mPa·s、全血还原黏度（16．81±3．32）mPa·s、红细胞聚集指数（1．26±0．31）、红细胞变形指数（0．64±0．27）与对照组治疗后比较，差异有统计学意义（P均〈0．05）。结论丹红注射液治疗慢性呼吸衰竭急性加重期临床疗效及安全性好。

Objective To study the clinical effect of treating acute exacerbation of chronic respiratory failure with Danhong injection. Methods According to random number table, 64 cases of acute exacerbation of chronic respiratory failure were divided randomly into 2 groups, with 32 cases in each group. Both groups were given correspondingly conventional symptomatic treatment （including oxygen, anti-inflammatory, antispasmodic, sputum, etc.）. On this basis, the treatment group was added Darthong injection 30 ml＋5%glucose infusion 250 ml, once a day, continuous therapy for 14 days. Results The total effective rate was 87.50% and 65.63% in Danhong injection treatment group and conventional treatment group respectively, showing obvious difference between 2 groups （x^2=4.267, P〈0.05）. The blood low shear viscosity （7.11 ±1.60） mPa ·s, high shear viscosity of whole blood （3.30±0.83） mPa · s, plasma viscosity （1.28±0.32） mPa · s, whole blood reduced viscosity （ 16.81± 3.32） mPa · s, erythrocyte aggregation index （ 1.26 ±0.31 ）, erythrocyte deformation index （0.64±0.27） in the Danhong injection treatment group all had statistical significance compared to the conventional treatment group（P〈0.05）. Conclusion Clinical efficacy and safety of Danhong injection in treating acute exacerbation of chronic respiratory failure were good.