短暂性脑缺血发作患者血浆溶血磷脂酸水平变化及不同剂量阿司匹林治疗效果研究

Study on the changes of lysophosphatidic acid levels in transient ischemic attack patients and the effect of different doses of Aspirin

目的：探讨短暂性脑缺血发作患者血浆溶血磷脂酸（LPA）水平变化及不同剂量阿司匹林治疗效果。方法：选取我院2008年10月～2010年12月收治的短暂性脑缺血患者80例为研究组，选择同期同年龄段健康体检者80例为对照组，观察两组LPA水平差异。研究组患者分别给予阿司匹林25mg／d（A组），75mg／d（B组）、200mg／d（C组），观察不同剂量阿司匹林对患者LPA水平及短暂性脑缺血发作的影响。结果：研究组患者血浆LPA水平明显高于对照组，两组比较，差异有统计学意义（t=8．726，P〈0．05），研究组患者治疗后A、B、C组LPA水平均较治疗前下降。但B、C组治疗前后比较，差异有统计学意义（t=5．169、8．874，P〈0．05），A组治疗前后比较，差异无统计学意义（t=0．726．P〉0．05）。三组治疗后LPA水平及3个月内脑缺血内发作次数C组最少，B组次之，A组最多，三组间比较，差异有统计学意义（F=7．649、8．021，P〈0．05）。结论：短暂性脑缺血发作患者血浆溶血磷脂酸水平明显升高，高剂量阿司匹林可明显减少血浆溶血磷脂酸水平及脑缺血发作次数：在无禁忌证的情况下可作为临床治疗的有效方法。

Objective： To investigate the changes of lysophosphatidic acid （LPA） levels in transient ischemic attack （TIA） patients and the effect of different doses of Aspirin. Methods： 80 TIA patients in our hospital from October 2008 to De- cember 2010 were selected as the study group, the healthy persons in the same period of the same age were chosen as con- trol group, LPA levels of the two groups were observed. Patients in the study group were given Aspirin 25 mg/d （group A）, 75 mg/d （group B）, 200 mg/d （group C）, the impact of different doses of Aspirin on LPA levels and cerebral ischemia attack were observed. Results： Plasma LPA level of the study group was significantly higher than that of the control group, the difference was statistically significant （t=8.726,/）〈0.05）; LPA level of study group after treatment all significantly de- creased than before treatment, However, that of B, C group was significantly lower than before treatment （t=5.169, 8.874, P〈0.05）, and there was no significant difference of LPA level of group A before and after treatment （t=0.726, P〉0.05）. After treatment, levels of LPA and ischemic attack number in 3 months were the most in group A, followed by group B, and the lest in group C, the difference of the three groups was statistically significant （F=7.649,8.021, P〈0.05 ）. Conclusion： LPA level of TIA patients is significantly high, high-dose Aspirin can significantly reduce the LPA level and the number of is- chemic attack, with no contraindications, it can be an effective treatment way.