氨溴索不同给药途径治疗新生儿胎粪吸入性肺炎的疗效观察

Observation of curative effect on Ambroxol by two ways in treating meconium aspiration pneumonia of newborn

目的:观察氨溴索不同给药途径治疗新生儿胎粪吸入性肺炎的临床疗效和安全性。方法:将90例新生儿胎粪吸入性肺炎患儿随机分为治疗组及对照组,每组各45例,两组均采取综合性治疗措施。治疗组加用氨溴索经医用压缩雾化机雾化吸入治疗,每次15 mg,bid,疗程5 d;对照组给予盐酸氨溴索15 mg/(kg.d)加入10%葡萄糖注射液10 ml,bid,静脉滴注,疗程5 d。观察对比两组疗效。结果:治疗组在脉搏血氧饱和度恢复时间、呼吸困难改善时间及平均住院天数上优于对照组,吸痰次数减少(均P<0.05),观察发现治疗组临床副作用更少。结论:氨溴索雾化治疗新生儿胎粪吸入性肺炎具有更好的疗效,更高的安全性,值得临床推广应用。

Objective： To observe the effect and safety of Ambroxol in treating meconium aspiration pneumonia of newborn by intravenous injection and aerosol inhalation. Methods： 90 cases of meconium aspiration pneumonia of newborn were randomly divided into treatment group （45 cases） and control group （45 cases）. Both groups were given the same routine treatment. The treatment group was administrated with aerosol inhalation of Ambroxol 15 mg twice a day, for 5 days, while the control group was administrated with intravenous injection Ambroxol 15 mg/（kg.d） twice a day, for 5 days. The therapeutic effects of the two groups were observed. Results： The improvement time of pulse oxygen saturation, the time of breathe approach to normal status and hospitalization time were shortened in treatment group, the number of times of sputum aspiration was decreased （all P〈0.05）. The treatment group had less side effects than the control group. Conclusion： Aerosol inhalation of Ambroxol in treating meconium aspiration pneumonia of newborn is effective, safe and worth popularizing.