慢性乙型病毒性肝炎患者幽门螺杆菌感染与肝纤维化程度相关性研究

Research of correlation between infection of Helicobacter pylori and stages of liver fibrosis in chronic hepatitis B patients

目的探讨慢性乙型病毒性肝炎(CHB)患者中幽门螺杆菌(Hp)感染与肝纤维化程度的相关性。方法观察61例CHB患者,经肝组织病理检查明确肝纤维化分期,同时行14 C-尿素呼气试验检测患者Hp感染的程度。观察Hp阳性组(n=18)和阴性组(n=43)的肝纤维化分期(S0～1=33,S2=15,S3～4=13)的差别及不同肝纤维化分期的14 C滴度的差别,用受试者工作特征(ROC)曲线评价14 C滴度辅助诊断肝纤维化的能力。结果 S0～1和S2～4在Hp阳性组和阴性组中的比率差异无统计学意义(P>0.05),S0～1、S2和S3～43组患者的14 C滴度差异无统计学意义(P>0.05);14 C滴度和肝纤维化分期的相关系数0.107(P>0.05),ROC曲线分析显示ROC下面积(AUC)0.444(95%CI=0.297～0.590)。结论 Hp在CHB中的感染阳性率及其滴度与肝纤维化分期无相关性。

Objective To discuss the correlation between infection of Helicobacter pylori（Hp） and stages of liver fibrosis in chronic hepatitis B（CHB） patients. Methods The study enrolled 61 cases with CHB whose stages of liver fibrosis were diagnosed by liver biopsy and whose infectivities（S0-1=33,S2=15,S3-4=13） of Hp were estimated by -urea breath test.The difference of liver fibrosis stages between Hp positive group（n=18） and negative group（n=43） was observed.The difference of drops were also valued among the different liver fibrosis stages.The ability of drops aided diagnosis liver fibrosis was assessed by the receiver operating characteristic curve（ROC）. Results There was little difference in the ratio of S0-1 and S2-4 between Hp positive group and negative group（P0.05）.There were little differences in drops among the groups of S0-1,S2 and S3-4（P0.05）.The correlation coefficient between drops and stages of liver fibrosis was 0.107（P0.05）.The area under of ROC（AUC） was 0.444（95%CI=0.297-0.590）. Conclusion There are no correlations between the infection ratio of Hp, drops and stages of liver fibrosis in chronic hepatitis B.