膀胱浸润性尿路上皮癌伴腺性分化(附两例报告并文献复习)

Infiltrating urothelial carcinoma of the bladder with glandular differentiation (a report of two cases with review of literatures)

目的:探讨膀胱浸润性尿路上皮癌伴腺性分化的临床病理特征、诊断及鉴别诊断。方法:回顾分析2例患者的临床及病理资料,结合文献复习并进行讨论。结果:2例患者均为男性,年龄分别为60岁和69岁,手术后均未复发。肿瘤直径为2 cm和3 cm,菜花状;组织学以尿路上皮癌与腺性成分混合为特征,免疫组化CKH、CKpan及p63阳性,PSA、P504S、CgA、Syn及SMA阴性,Ki-67约60%阳性,p53约10%阳性。结论:该肿瘤临床罕见,经病理组织学确诊,需与多种疾病鉴别。

Objective： To study the clinicopathological features,diagnosis and differential diagnosis of infiltrating urothelial carcinoma of the bladder with glandular differentiation.Methods： A retrospective review of the clinical and pathological data was used in 2 cases of the patients with tumor.The literatures were reviewed.Results： 2 cases of infiltrating urothelial carcinoma of the bladder with glandular differentiation were males,60 and 69 years in age respectively without recurrence after tumor resection.The tumors were diameter 2 cm and 3 cm in size,cauliflower-like.Histologically,2 cases showed presence of urothelial carcinoma and glandular component.Immunohistochemically,the tumors were positive for CKH,CKpan and p63,but negative for PSA,P504S,CgA,Syn and SMA.60% of tumor cells were positive for Ki-67 and 10% of tumor cells were positive for p53.Conclusion： Infiltrating urothelial carcinoma of the bladder with glandular differentiation is rare in clinic,whose diagnosis relying on histopathology.The tumor should be differentiated from other diseases.