摘要
目的:研究普伐他汀对兔激素性股骨头坏死组织的影响。方法:24只实验大白兔随机分为3组,每组各8只。治疗组:激素注射造模成功后,予以普伐他汀药物灌胃治疗;模型组:激素注射造模后予以生理盐水灌胃处理;对照组:生理盐水灌胃处理。治疗结束后观察3组兔股骨头组织学变化情况。结果:与模型组比较,治疗组毛细血管数、管径及骨陷窝空缺百分比均有显著改善(P<0.05)。结论:普伐他汀可有效治疗兔激素性股骨头坏死。
Objective： To study the effect of pravastatin on tissue of rabbit femoral head necrosis induced by hormone.Methods： Twenty-four experimental rabbits were randomly divided into 3 groups,eight rabbits in ever group.Treatment group： pravastatin was used by gavage treatment after models were constructed by hormone;models group： saline was used by gavage treatment after models were constructed by hormone;control group： saline was used by gavage treatment.The changes of femoral heads tissue in 3 groups were observed.Results： Compared with the models group,the number and diameter of capillaries,percentage of vacant lacuna in treatment goup improved significantly（P0.05）.Conclusion： Pravastatin has a good effect on the femoral head necrosis in rabbits induced by hormone.
出处
《现代医学》
2011年第5期564-565,共2页
Modern Medical Journal
关键词
普伐他汀
股骨头坏死
组织
兔
pravastatin
femoral head necrosis
tissue
rabbits
