硼替佐米治疗继发性浆细胞白血病1例并文献复习

Secondary plasma cell leukemia treated with bortezomib-based regimens:one case report and literature review

目的:探讨硼替佐米治疗浆细胞白血病的疗效。方法:报道1例继发性浆细胞白血病患者应用硼替佐米治疗的疗效,对硼替佐米治疗浆细胞白血病的相关文献进行复习。结果:该例患者经包括自体造血干细胞移植在内的多种治疗,二次复发并进展为继发性浆细胞白血病,经硼替佐米为基础的方案治疗后获得满意的近期疗效,文献复习显示硼替佐米治疗浆细胞白血病有效率高,耐受性好,但长期疗效尚难改善。结论:硼替佐米为基础的方案治疗浆细胞白血病可获得较好的近期疗效,可作为该类患者的一线治疗药物,但长期疗效尚需探讨新的治疗措施。

Objective：To explore the effecti of bortezomib-based regimenon on plasma cell leukemia.Method：Repart one case of secondary plasma cell leukemia were treated with bortezomib-based regimen.The literature was reviewed on the bortezomib-based therapy for PCL.Result：The patient who was initially diagnosed as multiple myeloma,and was treated many times including auto-stem cell transplantation.After relapsed two times,the patient was progressed to secondary plasma cell leukemia.The patient was achieved satisfactory response was after treated with bortezomib-based regimen.The literature review found that there was a high remission rate and good tolerance by bortezomib-based regimen for PCL.Conclusion：Bortezomib-based regimencan achieve a satisfactory remission rate and could be first-line therapy for PCL,though long term remission required.