原发性胃黏膜相关淋巴组织淋巴瘤29例临床分析

Clinical Analysis of 29 Cases With Primary Gastric Mucosa-associated Lymphoid Tissue Lymphoma

目的:分析胃黏膜相关淋巴组织(MALT)淋巴瘤临床、胃镜、病理特征,提高早期检出率。方法:回顾性分析经胃镜活检及手术后病理证实胃MALT淋巴瘤29例患者的临床资料。结果:29例患者临床表现多样,以上腹痛多见,幽门螺杆菌(HP)感染率高达93%,胃镜下病灶好发于胃窦、胃体,但胃镜下活检阳性率较低,仅占48%。结论:胃MALT淋巴瘤临床表现无特异性,胃镜下表现多样,提高临床和胃镜医师对本病的认识以及提高胃镜下活检阳性率活检标本加做免疫组织化学染色是早期诊断胃MALT淋巴瘤的关键。

Objective： To improve the early detection rate of gastric mucosa-associated lymphoid tissue （MALT） lymphoma by analyzing its clinical, endoscopic and pathological features. Methods： Clinical data of 29 patients with gastric MALT lymphoma confirmed by endoscopic biopsy and the pathological findings of tissues obtained from surgical operation were analyzed retrospectively. Results： Various clinical features were seen in 29 patients, in which upper abdominal pain was the most common one and the rate of helicobacter pylori （HP） infection was 93%. The lesions commonly located at gastric antrum and gastric corpus endoscopically, but with a lower positive rate （48%） by endoscopic biopsy. Conclusions： There were no special clinical features in patients with gastric MALT lymphoma, and with diverse endoscopic features. To improve the recognition of the disease and increase the positive rate of endoscopic biopsy with immunohistochemical strains play the key roles for the early diagnosis of gastric MALT lymphoma.