艾司西酞普兰与文拉法辛缓释片治疗抑郁症的对照研究

Comparison of efficacy and safety between Eseitalopram and Venlafaxin in the treatment of depression

目的:探讨艾司西酞普兰与文拉法辛缓释片治疗抑郁症的效果和安全性。方法:60例抑郁症患者随机分为艾司西酞普兰组和文拉法辛缓释片组,分别给予艾司西酞普兰10～20 mg/d,文拉法辛缓释片75～225 mg/d,治疗6周。疗效采用Hamilton抑郁量表(HAMD)减分率评定,不良反应和安全性用副反应量表(TESS)和实验室检查评定。结果:艾司西酞普兰组有效率90.0%,治愈率36.7%;文拉法辛缓释片组有效率86.7%,治愈率40.0%,两组比较差异无统计学意义(P>O.05)。艾司西酞普兰主要不良反应为恶心、口干、困倦、头晕等,与文拉法辛缓释片差异无统计学意义(P>O.05)。结论:艾司西酞普兰治疗抑郁症患者安全有效,疗效和不良反应与文拉法辛缓释片相似。

Objective： To study the efficacy and safety of escitalopram and venlafaxin in the treatment of depression.Method： This was a randomized,open-label,6-week flexible dose study.Sixty patients diagnosed.as depression based on criteria were randomly assigned to escitalopram group treated with escitalopram 10~20 mg per day or venlafaxin group with venlafaxin sustained-release tablets 75~225 mg per day.Clinical effectiveness was evaluated with HAMD,and adverse reactions and safety were assessed with TESS and laboratory examina tion.Results： The response rate and remission rate were 90.0% and 36.7% in escitalopram group and were 86.7% and 40.0%in venlafaxin group respectively,without significant differences between two groups for both rates.The main adverse reactions were lack of appetite,nausea,dry mouth and dizziness in both groups.There were no significant differences between two groups.Conclusion： Escitalopram could be demonstrated as effective and tolerable as venlafaxin.