甲亢患者β_2-微球蛋白与血脂水平相关性研究

A Relative Analysis between β_2-Microglobulin and Blood Fat in Patients with Graves' Disease

目的:探讨甲亢患者β2-微球蛋白含量与血脂水平的相关性。方法:以甲状腺功能亢进症患者40例作为观察组,另选择同期在我院进行体检的健康人群40例为对照组,分别于治疗前和治疗后检测患者血清和尿β2-微球蛋白、血外周血载脂蛋白、血脂,并进行血清和尿β2-微球蛋白与血脂的相关性分析。结果:治疗前甲亢组血清和尿β2-微球蛋白均高于对照组(P<0.01);TC、TG、HDL-C、LDL-C和APOB均低于对照组(P<0.01);治疗后,血清和尿β2-微球蛋白与治疗前相比均有所下降(P<0.01),TC、TG、HDL-C、LDL-C和APOB与脂类前相比均有所升高(P<0.01);血清和尿β2-微球蛋白与TC、TG、HDL-C、LDL-C和APOB均呈负相关。结论:甲亢患者血清和尿β2-微球蛋白与血脂关系密切,可作为评价患者脂质代谢状态和病情变化的重要指标。

Objective： To explore the relationship between β 2-microglobulin and blood fat in patients with Graves＇ disease. Methods： 40 patients with Graves＇ disease were selected as observation group, and 40 healthy people were selected as controi group. To detect serum, urine contents of β 2-microglobulin, APOB and blood fat before and after treatment. To analyze the relationship of the serum, urine contents of β 2-microglobulin and blood fat. Results： The levels of serum, urine of β2-microglobulin were higher in observation group than those in control group before treatment, while the level of TC, TG, HDL-C, LDL-C and APOB were lower in observation group than those in control group. The levels of serum, urine of β 2-microglobulin decreased in observation group after treatment compared with those before treatment, while the level of TC, TG, HDL-C, LDL-C and APOB increased after treatment compared with those before treatment. The levels of serum, urine of β 2-microglobulin were negative correlation to the levels of TC, TG, HDL-C, LDL-C and APOB. Conclusion： There is a closely relationship between β 2-microglobulin and blood fat in patients with Graves＇ disease. β 2-microglobulin can be used to value metabolism of blood fat and the change of pathogenetic condition.