肿瘤微环境中相关细胞的研究进展

The Development of Cell in the Tumor Microenvironment

肿瘤的微环境对肿瘤的发生,发展具有重要的意义。实体瘤中除肿瘤细胞外存在大量的非肿瘤细胞,如肿瘤间质细胞、成纤维细胞、血管内皮细胞、免疫细胞、脂肪细胞等等,这一系列的细胞与肿瘤细胞相互作用,通过一系列的因子分泌而促使肿瘤的进一步的恶化,目前传统的抗肿瘤药物研究往往局限于肿瘤细胞本身而忽略了肿瘤周围的细胞作用,使得肿瘤久治不愈。将来的药物开发应该围绕肿瘤细胞为主体的同时,兼顾微环境中的其他细胞,多靶点治疗肿瘤,真正实现肿瘤的治愈。

The tumor microenvironment have great significance to tumor occurrence and development, Solid tumors, in addition to a large number of tumor there is a lot of non-tumor ceils such as tumor stroma cells, fibroblasts, vascular endothelial cells, immune cells, lipocyte, etc. This series of cells and tumor cell is interaction, through a series of secreting factor which promote further deterioration of the tumor. Study of traditional anticancer drugs currently often limited to the tumor cells themselves but neglecting of the role of the cells around the tumor cells, making the cancer permanently. Future drug development should focus on the tumor cells as the main body, while taking into account other cells in the micro-environment, multi-target treatment of cancer, which was really cure the cancer.