倍他乐克注射液治疗急性心肌梗死疗效观察

Metoprolol injection in the treatment of acute myocardial infarction

目的探讨静脉注射倍他乐克治疗急性心肌梗死的有效性及安全性。方法 33例急性心肌梗死患者,排除严重低血压、严重心动过缓、Ⅲ度房室传导阻滞及心源性休克情况,予3支倍他乐克针剂缓慢静脉注射,每支5mg,共15mg,间隔5min,观察心率、血压、心功能、ST段抬值总和、胸痛程度及1周内恶性心律失常、猝死、再发心肌梗死等情况。结果静脉注射倍他乐克后,患者血压、心率及收缩压与心率乘积(SBPHR)、胸痛积分均明显下降,而心梗相关导联ST段抬高值的总和(∑ST)也有明显下降,心功能无明显下降,1周内未发生不断改进性心律失常、猝死、再发心肌梗死。结论早期静脉注射倍他乐克可有效预防急性心肌梗死患者发生心力衰竭和预防猝死、再发心肌梗死。

Objective To study the effects of intravenous metoprolol for treatment of acute myocardial infarction in safety and efficacy.Methods 33 cases of patients with acute myocardial infarction,the exclusion of severe hypotension,severe heart beat bradycardia,atrioventricular block and cardiogenic shock,to the 3 times he le g injection slow intravenous injection,each branch of 5 mg,15 mg,5 min interval,heart rate,blood pressure,heart function,value of the sum of ST segment carried within 1 weeks,chest pain and malignant arrhythmia,sudden cardiac death,recurrent myocardial infarction;Results intravenous metoprolol g,blood pressure,heart rate and systolic blood pressure and heart rate（SBP HR product）,chest pain score decreased significantly,while ST segment elevation myocardial infarction related to the sum of the values（and ST） also decreased significantly,cardiac function without obvious decline,1 weeks without improvement of arrhythmias,sudden death,recurrent myocardial infarction;Conclusion Early intravenous metoprolol for G can be effective in preventing acute myocardial infarction occurring in patients with heart failure and prevention of sudden death,recurrent myocardial infarction.