牙周基础治疗对牙周炎患者龈沟液肿瘤坏死因子-α含量的影响

Effect of Periodontal Initial Therapy on Gingival Crevicular Fluid Tumor Necrosis Factor-alpha In Chronic Periodontitis Patients

目的观察牙周基础治疗慢性牙周炎患者的临床牙周指数和龈沟液肿瘤坏死因子-α水平的影响。方法 30例慢性牙周炎患者,于治疗前、牙周基础治疗后2周及10周滤纸条法收集患牙龈沟液,并记录相关的临床指标,包括菌斑指数、牙龈指数、探诊出血、探诊深度和临床附着丧失水平;放免法检测中龈沟液TNF-α水平。结果牙周基础治疗后2周及10周慢性牙周炎患者的临床牙周指数和龈沟液TNF-α水平显著低于治疗前。结论牙周基础治疗能改善慢性牙周炎患者的临床牙周指数,并降低龈沟液TNF-α的含量。

Objective This study sought to evaluate the effect of peripodontal initial therapy on gingival crevicular fluid tumor necrosis factor-alpha and on clinical parameters in patients with periodontal disease.Methods Data were obtained from 30 patients diagnosed with chronic periodontitis.Clinical parameter and GCF samples were obtained at time before,2 weeks and 10 weeks after pedipodontal initial therapy.GCF was collected using a paper strip,and tumor necrosis factor-alpha levels were determined by radioimmunoassay.Results The clinical parameters and tumor necrosis factor-alpha levels in GCF decreased significantly two weeks and ten weeks after peripodontal initial therapy in patients with periodontal disease.Conclusion Peripodontal initial therapy improved clinical parameters in chronic periodontitis patients accompanied with necrosis factor-alpha levels in GCF decreased.