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肝癌行肝移植术后防止肿瘤复发的策略 被引量:1

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摘要 自1996年肝癌肝移植米兰标准的发布及应用以来,肝移植在治疗肝癌上取得了良好的效果,5年生存率在60~80%。由于术前外周血潜在肿瘤细胞转移,术中肿瘤的种植以及术后免疫抑制药物的应用,肝癌肝移植术后仍然有较高的复发率,严重影响肝癌肝移植预后,即使符合米兰标准得肝癌行肝移植术后肿瘤复发率也达10%~20%。此外,对于肝癌肝移植术后肿瘤复发的患者,目前尚无有效的治疗手段。
作者 饶建华 张峰
出处 《肝胆外科杂志》 2011年第5期333-335,共3页 Journal of Hepatobiliary Surgery
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参考文献14

  • 1Mazzaferro V, Llovet JM, Miceli R, et al. Predicting survival after liver transplantation in patients with hepatocellular carcinoma beyond the Milan criteria: A retrospective, exploratory analysis. Lancet On- col, 2009; 10(1) : 35 -43.
  • 2Roayaie S, Frischer JS, Emre SH, et al. Long-term results with mul- timodal adjuvant therapy and liver transplantation for the treatment of hepatocellular carcinomas larger than 5 centimeters. Ann Surg, 2002; 235(4): 533-539.
  • 3Bismuth H, Majuo PE, Adam R. Liver transplantation for hepatocel- lular carcinoma. Semin Liver Dis, 1999; 19(3) : 311 -322.
  • 4Freise CE, Ferrell L, Liu T, et al. Effect of systemic cyclosporine on tumor recurrence after liver transplantation in a model of hepatoceBu- lar carcinoma. Transplantation, 1999; 67(4) : 510 -513.
  • 5Toso C, Trotter J, Wei A, et al. Total tumor volume predicts risk of recurrence following liver transplantation in patients with hepatocellu- lar carcinoma. Liver Transpl, 2008; 14(8): 1107-1115.
  • 6汪国营,杨扬,张琪,李华,陈冠中,易述红,许赤,汪根树,张剑,易慧敏,姜楠,傅斌生,赵辉,李敏如,陈颖华,蔡常洁,陆敏强,陈规划.术前中性粒细胞与淋巴细胞比值对肝癌肝移植术后肿瘤复发的影响[J].中华医学杂志,2011,91(22):1519-1522. 被引量:9
  • 7Mazzaferro V, Regalia E, Doci R, et al. Liver transplantation for the treatment of small hepatocellular carcinomas in patients with cirrhosis. N Engl J Med, 1996; 334(11) : 693 -699.
  • 8Yao FY, Fen'ell L, Bass NM, et al. Liver transplantation for hepato- cellular carcinoma: expansion of the tumor size limits does not ad- versely impact survival. Hepatalogy, 2001; 33(6) : 1394 -1403.
  • 9Wong LL, Tanaka K, Lau L, Komura S. Pre-transplant treatment of hepatocellular carcinoma: assessment of tumor necrosis in explanted livers. Clin Transplant. 2004; 18(3) : 227 -234.
  • 10Man K, Lo CM, Xiao JW, et al. The significance of acute phase small-for-size graft injury on tumor growth and invasiveness after liver transplantation. Ann Surg 2008 ; 247 : 1049 - 1057.

二级参考文献16

  • 1樊嘉,徐泱,周俭.肝癌患者肝移植适应证的选择[J].中华医学杂志,2005,85(24):1662-1664. 被引量:23
  • 2贺轶锋,樊嘉,周俭,吴志全,邱双健,黄晓武,余耀,孙健,肖永胜,杨国欢,宋康,王征,汤钊猷,王玉琦.影响肝癌肝移植预后的高危因素分析及诊治经验[J].中华医学杂志,2006,86(18):1232-1235. 被引量:27
  • 3徐泱,樊嘉,周俭,邱双健,吴志全,余耀,黄晓武,汤钊猷,王玉琦.肝癌肝移植预后相关因素分析[J].中华医学杂志,2007,87(30):2101-2104. 被引量:6
  • 4Mazzaferro v,Regalia E,Doci R,et al.Liver transplantation for the treatment of small hepatocellular carcinomas in patients with cirrhosis.N Engl J Med,1996,334:693-699.
  • 5Coussens LM,Werb Z.Inflammation and cancer.Nature,2002,420:860-867.
  • 6Walsh SR,Cook EJ,Goulder F,et al.Neutrophil-lymphocyte ratio as a prognostic factor in colorectal cancer.J Surg Oncol,2005,91:181-184.
  • 7Halazun KJ,Aldoori A,Malik HZ,et al.Elevated preoperative neutrophil to lymphocyte ratio predicts survival following hepatic resection for colorectal liver metastases.Eur J Surg Oncol,2008,34:55-60.
  • 8Gomez D,Farid S,Malik HZ,et al.Preoperative neutrophil-to-lymphocyte ratio as a prognostic predictor after curative resection for hepatocellular carcinoma.World J Surg,2008,32:1757-1762.
  • 9Halazun KJ,Hardy MA,Rana AA,et al.Negative impact of neutrophil-lymphocyte ratio on outcome after liver transplantation for hepatocellular carcinoma.Ann Surg,2009,250:141-151.
  • 10Jonas S,Bechstein WO,Steinmuller,T et al.Vascular invasion and histopathologic grading determine outcome after liver transplantation for hepatocellular carcinoma in cirrhosis.Hepatology,2001,33:1080-1086.

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