Facile Synthesis of N-Sulfonylcyclothioureas in Water

从在水里的房间温度的 N-monosulfonyl 肼， CS2 和氯乙酸的酸的 N-sulfonylcyclothioureas 的顺序的一个壶合成被描述。当高度有毒的 thiophosgene 和器官的溶剂不在时，这个方法是环境地良性的。象有用副产品的简单反应条件，产品的容易的纯化，好收益和 thioglycolic 酸也是这方法论的重要属性。包括双人脚踏车反应的嘴巧的机制被建议。

A sequential one-pot synthesis of N-sulfonylcyclothioureas from N-monosulfonyl diamines, CS2 and chloroace- tic acid at room temperature in water is described. In the absence of highly toxic thiophosgene and organic solvents, this method is environmentally benign. Simple reaction conditions, easy purification of the products, good yields and thioglycolic acid as the useful byproduct are also important attributes of this methodology. The plausible mechanism including tandem reactions is proposed.