非酒精性脂肪性肝病与代谢综合征关系研究进展

Advances in the relationship between metabolic syndrome and nonalcoholic fatty liver disease

非酒精性脂肪性肝病的发病与胰岛素抵抗及其表型有关。胰岛素抵抗和代偿性高胰岛素血症是代谢综合征的中心环节。非酒精性脂肪性肝病是代谢综合征的临床疾病谱之一。非酒精性脂肪性肝病与动脉粥样硬化性心血管疾病、2型糖尿病及代谢综合征临床症候群的关系密切,本文就非酒精性脂肪肝与代谢综合征的关系作一综述。

The mechanism of nonalcoholic fatty liver disease（NAFLD） is related to insulin resistance and its phenotype.Insulin resistance and compensatory hyperinsulinemia play a central role in the pathogenesis of metabolic syndrome（MS）.NAFLD is one of the clinical manifestations of MS.NAFLD is associated with atherosclerotic cardiovascular disease,type 2 diabetes and the clinical components of MS.We review the relationship between MS and NAFLD in this article.