神经调节在功能性胃肠病发病中的作用及其研究进展

Progress in understanding the role of neuromodulation in the pathogenesis of functional gastrointestinal disorders

功能性胃肠病是消化系统的常见疾病,其发生与脑-肠轴的异常密切相关.脑-肠轴神经调节过程的紊乱产生了以胃肠道动力改变和疼痛、腹胀为主症的消化系疾病.本文总结了脑-肠轴的神经调节机制和介入治疗进展,探讨了神经调节介入治疗功能性胃肠病的临床研究前景.

Functional gastrointestinal disorders （FGIDs） are a group of common digestive diseases whose pathogenesis is closely related to the abnormal brain-gut axis. Disturbances of the neuromodulatory processes in the brain-gut axis generate functional digestive disorders mainly centered on the pain, bloating symptoms and motility diseases. This article reviews neuromodulatory mechanism aspects of the brain- gut axis and discusses the dinical prospects for the neuromodulatory interventional treatment of FGIDs.