淋巴瘤微环境的研究进展

Progress of Studies on Microenvironment of Lymphoma——Review

诸多研究表明,淋巴瘤的发生与染色体易位、参与细胞周期和凋亡途径的分子改变有关。但是,T细胞和B细胞肿瘤细胞的生存同样依赖于这些细胞与组成淋巴瘤微环境的诸多细胞的相互作用。淋巴瘤微环境由不同的免疫细胞、辅助基质细胞及众多分子组成,与肿瘤细胞相互作用促进肿瘤的生长和药物耐药。淋巴瘤是一类异质性很强的疾病,不同类型间预后差别很大,而其微环境对此起着重要的作用。本文阐述了近来研究较多的组成淋巴瘤微环境的细胞及分子成分,包括巨噬细胞、黏附分子及趋化因子,以及微环境在经典型霍奇金淋巴瘤、滤泡性淋巴瘤及弥漫大B细胞淋巴瘤中所起的作用,显示微环境对淋巴瘤预后的影响及针对肿瘤微环境来治疗淋巴瘤的新途径。

Many studies indicate that lymphoid neoplasms are related with chromosome translocations and the molecular alterations involving in the cell cycle and/or apoptotic pathways.However,survival of B and T tumor cells also depends on interactions of these cells with the accompanying cells comprising the lymphoma microenvironment.Immune cells,stromal cells and numerous moleculars together make up the microenvironment and have functional interaction with tumor cells,promoting tumor growth and drug resistance.Different types of lymphoma have various clinical courses,therapy responses and prognoses,which show a close relationship with the microenvironment.This review summarizes several components of lymphoma microenvironment including macrophages,adhesion molecules and chemokines and the roles of microenvironment in classic non-Hodgkin′s lymphoma,follicular lymphoma,diffuse large B-cell lymphoma,suggesting that the microenvironment influence the prognosis of lymphoma,targeting microenvi-ronment may be a potential method in lymphoma therapy.