干细胞移植治疗小儿脑瘫的临床疗效:40例报告

Stem cells transplantation in therapy of children cerebral palsy: report of 40 cases

目的分析和总结应用脐带间充质干细胞对小儿脑瘫患者的运动功能疗效。方法常规检查后,随机筛选适合进行干细胞移植的脑瘫患儿40例,每隔一周进行1次,共四次为一个疗程的脐带间充质干细胞移植,移植方法包括静脉输注(1次)和腰椎穿刺蛛网膜下腔移植(3次);同时辅助常规神经营养药物和物理康复治疗,随访6个月至1年,平均8.5个月。应用小儿脑瘫粗大运动评价量表(GMFM-88),改良Ashworth法(肌张力评定)和SPSS对术前、术后患儿的粗大运动功能进行统计分析。结果一个干细胞移植治疗疗程结束后,患儿自身对比的粗大运动能力均得到不同程度提高。随访发现,患儿出院6个月后的各项运动指标也较出院时有明显改善。结论干细胞移植可不同程度改善脑瘫患儿的运动功能,其治疗机制有待进一步探讨。

Objective To analyze and summarize the effect of umbilical cord mesenchymal stem cells（UCMSCs） transplantation on the motor functions of children with cerebral palsy.Methods After regular body check,40 children patients were selected randomly for UCMSCs transplantation.UCMSCs transplantation was performed every other week with four times as one treatment course,which includes venoclysis transplantation for once and subarachnoid space transplantation for three times by lumbar puncture.Neurotrophic factors and physical therapy were also applied to the patients.All the patients were followed-up for 6~12 months（average 8.5 months）.Gross Motor Function Measure-88 and Ashworth scale were applied for motor function assessment;SPSS statistical software was used for the analysis of results.Results After one treatment course,the motor functions were improved at different degrees and they were continuously improved 6 months after discharge.Conclusion UCMSCs transplantation can improve the motor functions of cerebral palsy children patients significantly,but the mechanism needs the further research.