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软骨肉瘤中MMP-1及TIMP-1的表达及意义 被引量：4

Expression and significance of matrix metalloproteinase 1 and its inhibitor in chondrosarcoma
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摘要 目的研究软骨肉瘤组织中MMP-1及TIMP-1的表达情况,探讨二者在软骨肉瘤间质浸润中的作用机制。方法收集32例软骨肉瘤标本和10例内生性软骨瘤标本,分别用免疫组化法、Western blot法、实时荧光定量PCR法检测MMP-1、TIMP-1及Ⅱ型胶原的表达情况。结果 MMP-1和TIMP-1在软骨肉瘤中高表达,并随软骨肉瘤恶性程度的升高而加强(P<0.01);Ⅱ型胶原在软骨肉瘤中的表达降低(P<0.01)。结论 MMP-1在软骨肉瘤中通过对细胞外基质(extracellular matrixc,ECM)的降解,来增加软骨肉瘤的侵袭能力。 Purpose To study the expression and significance of matrix metalloproteinase 1（MMP-1） and tissue inhibitor of metalloproteinase 1（TIMP-1） in chondrosarcoma.Methods The expression of MMP-1,TIMP-1 and collagen Ⅱ were determinated in 32 cases of chondrosarcoma specimens and 10 cases of enchodroma specimens by immunohistochemistry,Western blot and real-time quantitative fluorescent PCR.Results The positive expression of MMP-1 and TIMP-1 in chondrosarcoma was higher than that of enchodroma tissues（P0.01）.The expression of collagen Ⅱ was decreased in chondrosarcoma（P0.01）.Conclusions MMP-1 can enhance chondrosarcoma＇s invasive capability through degradation of extracellular matrix.
作者 高峰 刘淑霞 郝军 王晓萌 赵玉峰
机构地区 河北医科大学第三医院病理科 河北医科大学病理学教研室
出处 《临床与实验病理学杂志》 CAS CSCD 北大核心 2011年第10期1074-1076,共3页 Chinese Journal of Clinical and Experimental Pathology
基金 河北省医学科学研究重点课题(20100350)
关键词 骨肿瘤 软骨肉瘤 基质金属蛋白酶 基质金属蛋白酶抑制剂 Ⅱ型胶原 bone neosplsms chondrosarcoma MMP-1 TIMP-1 collagen Ⅱ
分类号 R738.3 [医药卫生—肿瘤]
  • 相关文献

参考文献6

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二级参考文献9

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共引文献22

同被引文献60

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引证文献4

二级引证文献11

临床与实验病理学杂志
2011年 第10期

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