马来酸曲美布汀在结肠镜检查中的临床应用

The Clinical Application of Trimebutine Maleate in Colonoscopy

目的探讨马来酸曲美布汀对结肠镜检查患者和结肠镜操作的影响。方法将72例接受结肠镜检查的患者随机分为两组,各36例。治疗组于结肠镜检查前3 d开始服马来酸曲美布汀片100 mg/次,3次/d,至检查当日停服;对照组不服用此药物。观察两组患者在结肠镜检查过程中的腹痛、肠痉挛程度及肠道清洁程度,记录结肠镜到达回盲部时间。结果①腹痛评分:治疗组为1.7±0.6,对照组为2.2±0.8,治疗组腹痛程度明显低于对照组(P<0.05)。②肠痉挛评分:治疗组为1.9±0.6,对照组为2.4±0.8,治疗组肠痉挛程度明显低于对照组(P<0.05)。③肠道清洁率:治疗组为91.7%,对照组为75.0%,治疗组肠道清洁程度明显优于对照组(P<0.05)。④结肠镜到达回盲部时间:治疗组为11.9±3.7 min,对照组为15.7±4.3 min,治疗组结肠镜到达回盲部时间明显短于对照组(P<0.05)。结论马来酸曲美布汀可减轻结肠镜检查患者的腹痛、肠痉挛程度,改善肠道清洁程度,缩短检查时间,减轻患者痛苦,有利于内镜医师操作和完成检查。

Objective Discusses the influence of trimebutine maleate about colonoscopy patients and colonoscopy operation. Method 72 cases accepted eolonoscopy patients were randomly divided into two groups of every 36 cases, The treatment group was given trimebutine maleate（ 100 mg,3 time per day）for three days before colonoscopy, until that day. Stopping check. The control group didn＇ t take the drug. Observe two sets of patients abdominal pain, enterosepsis degree in colonoscopy process. Observe intestinal cleaning degree. The whole time for eolonoseopy reaching ileocecal junction was recorded. Results （~） The score of abdominal pain. in treatment group was 1.7 ± 0.6, and in control group was 2.2 ± 0.8. The abdominal pain degree was lower in the treatment group than that in the control group（ P 〈 0.05 ）. ② The score of enterosepsis in treatment group was 1.9 ± 0.6, and in control group was 2.4 ± 0.8. The enterosepsis degree was lower in the treatment group than that in the control group（ P 〈 0.05 ）. ③ Intestinal clean percentage in treatment group was 91.7%, and in control group was 75.0%. The cleanness of colon was better in the treatment group than that in the control group（ P 〈 0.05 ）. ④ The whoie time for eolonoscopy reaching ileocecal junction in treatment group was 11.9 ± 3.7 minutes, and in control group was 15.7 ± 4.3 minutes. The whole time for colonoscopy reaching ileocecal junction was less in the treatment group （P 〈 0.05 ）. Conclusion It＇ s suggested that application of trimebutine maleate can reduce abdominal pain and enterosepsis of patients in colonoscopy, improve the cleanness of colon. Shorten the examination time, relieve the pain of patients, for endoscopic physicians operation and complete inspection.