奥沙拉嗪联合甘草酸二铵对溃疡性结肠炎患者脂质过氧化损伤和IL-1β水平的影响

Effects of olsalazine in combination with diammonium glycyrrhizinate on lipid peroxidation and IL-1β levels in patients with ulcerative colitis

目的观察奥沙拉嗪联合甘草酸二铵治疗对溃疡性结肠炎患者血浆脂质过氧化损伤和IL-1β水平的影响。方法将活动期中度的66例溃疡性结肠炎患者随机分为两组:实验组34例,对照组32例。实验组给予奥沙拉嗪和甘草酸二铵联合治疗;对照组32例,给予奥沙拉嗪治疗,每组总疗程4周。采用随机双盲法比较治疗前后两组患者ox-LDL、MDA、SOD和IL-1β水平的变化情况。结果治疗前,两组患者ox-LDL、MDA和IL-1β水平均无统计学差异(均为P>0.05),两组患者血浆ox-LDL与MDA呈正相关性(r=0.452,P=0.033),而与SOD呈负相关性(r=-0.452,P=0.027);治疗4周后,实验组患者ox-LDL、MDA和IL-1β水平较治疗前显著降低(均为P<0.05),而SOD水平则显著升高(P<0.05,P<0.01),两组间ox-LDL、MDA、IL-1β水平和SOD活性的差异均具有统计学意义(P<0.05)。结论奥沙拉嗪与甘草酸二铵联合治疗能有效抑制溃疡性结肠炎患者IL-1β表达,减轻脂质过氧化损伤。

Objective To investigate the effect of olsalazine in combination with diammonium glycyrrhizinate on lipid peroxidation injury and IL-1β levels in patients with ulcerative colitis.Methods 66 patients were divided into a trial group（n=34） and a control group（n=32）.Patients in the trial group were given olsalazine and diammonium glycyrrhizinate,while those in the control group were given olsalazine only for a medication of 4 weeks.Plasma levels of ox-LDL,MDA,SOD and IL-1β in both groups were investigated before and after the treatment,using a randomized and double-blind approach.Results Before the treatment,there were no significant differences between the two groups in ox-LDL,MDA,SOD and IL-1β levels（P0.05）.Also,in both groups,plasma levels of ox-LDL were positively correlated with MDA（r=0.452,P=0.033）,but negatively correlated with SOD（r=0.452,P=0.027）.After the treatment for the trial group,SOD increased significantly（P0.05）,while levels of ox-LDL,MDA and IL-1β decreased significantly（P0.05）.Differences in these indexes were also statistically significant between two groups（P0.05）.Conclusion Olsalazine in combination with diammonium glycyrrhizinate has significant effects on suppressing IL-1β expression,leading to an apparent alleviation of lipid peroxidation-induced injuries in patients with ulcerative colitis.