期刊文献+

肝脏磁共振波谱分析对肝癌化疗栓塞后疗效评价的试验性研究 被引量:4

The experimental study of magnetic resonance spectroscopy imaging in estimating efficacy after chemoembolization of hepatocellular carcinoma
下载PDF
导出
摘要 目的:应用磁共振波谱(MRS)技术评价兔肝癌化疗栓塞的疗效。方法:建立兔肝癌模型,Seldinger's法股动脉插管行选择性肝动脉造影,采用化疗栓塞术(TACE)治疗,治疗前后行MRS扫描,记录MRS各峰的峰值。结果:TACE治疗后的肝脏肿瘤组织具有一个异常增高的PCr峰,治疗后的PME/PDE比例较治疗前明显降低。结论:MRS作为无创性检查方法,可用于评价化疗的栓塞疗效。 Objective: To explore the application value of magnetic resonance spectroscopy (MRS) imaging in evaluating the effect of transarterial chemoembolization (TACE). Methods: A rabbit model of transplantable hepatocellular carcinoma was established. Selective hepatic arteriography was treated by percutaneous transfemoral catheterization involving application of Seldinger's technique and transarterial chemoembolization was performed. MRS imaging was applied before and after the treatment and every peak value of MRS was recorded. Results: PCr peak of tumor tissue increased obviously after transcatheter arterial chemoembolization, and the ratio of PME/PDE decreased significantly. Conclusion: As minimally invasive methods of examination, MRS can be used to evaluate the the clinical efficacy of transcatheter arterial chemoembolization.
出处 《中国中西医结合影像学杂志》 2011年第5期394-396,F0002,共4页 Chinese Imaging Journal of Integrated Traditional and Western Medicine
基金 山东省教育厅科研项目(编号:J07WE03)
关键词 肝肿瘤 磁共振波谱学 化学栓塞 治疗性 动物实验 hepatocellular neoplasms magnetic resonance spectroscopy chemoembolization,tharapeutic animal experimentation
  • 相关文献

参考文献8

  • 1汪盛齐,杨小庆,邓钢,何仕诚,郭金和,牛焕章,陈晟.磁共振扩散加权成像评价肝癌介入术后疗效的临床及动物实验研究[J].东南大学学报(医学版),2006,25(5):357-361. 被引量:6
  • 2Li Z,Qiao H,Lebherz C,et al.Creatine kinase,a magnetic resonance detectable marker gene for quantification of liver-directed gene transfer[J].Hum Gene Ther,2005,16:1429-1438.
  • 3Swindle P,McCredie S,Russell P,et al.Pathologic characterization of human prostate tissue with proton MR spectroscopy[J].Radiology,2003,228:144-151.
  • 4柳曦,李欣,赵俊功,周承凯,冯敢生,戴文.兔VX_2肝癌模型制作及综合影像评价[J].实用放射学杂志,2002,18(2):132-134. 被引量:40
  • 5陈军,丁仕义.肝脏肿瘤的^(31)P磁共振波谱研究进展[J].现代生物医学进展,2006,6(11):128-130. 被引量:2
  • 6Yazici H,Altun M,Alatli C,et al.c-erbB-2 gene amplification in nasopharyngeal carcinoma[J].Cancer invest,2000,18:6-10.
  • 7Thulborn KR,Gindin TS,Davis D,et al.Comprehensive MR imaging protocol for stroke management:tissue sodium concentration as a measure of tissue viability in nonhuman primate studies and in clinical studies[J].Radiology,1999,213:156-166.
  • 8Saeki M,Ashida H,Imamura K,et al.Clinical application of 31P-MRS to malignant liver tumor:with an emphasis on evaluation of response to therapy[J].Nihon lqaku Hoshasen Gakkai Zasshi,1992,52:744-754.

二级参考文献24

  • 1刘强,王滨,武乐斌.^(31)PMR波谱分析在肝细胞癌、肝硬化及正常肝组织中的临床应用价值[J].实用放射学杂志,2005,21(5):493-496. 被引量:14
  • 2曾蒙苏,张宏伟,周康荣,陆宏祺,严惠芳.供影像学诊断实验的大鼠移植肝癌模型的可行性研究[J].临床放射学杂志,1996,15(1):56-59. 被引量:14
  • 3TURNER R,LE B D,MAIER J,et al.Echo-planar imaging of intravoxel incoherent motion[J].Radiology,1990,177(2):407-414.
  • 4TSURUDA J S,CHEW W M,MOSELEY M E,et al.Diffusion-weighted MR imaging of the brain:value of differentiating between extraaxial cysts and epidermoid tumors[J].AJR,1990,155 (5):1059-1068.
  • 5TIEN R D,FELSBERG G,FRIEDMAN H,et al.MR imaging of high-grade cerebral gliomas:value of diffusion-weighted echo-planar pulse sequence[J].AJR,1994,162 (3):671-677.
  • 6TAOULI B,VILGRAIN V,DUMONT E,et al.Evalution of liver diffusion isotropy and characterization of focal heoatic lesions with two single-shot echo-planar MR imaging sequences:prospective study in 66 patients[J].Radiology,2003,226(1):71-78.
  • 7MURTZ P,FLACKE S,TRABER F,et al.Abdomen:diffusion-weighted MR imaging with pulse-triggered single-shot sequences[J].Radiology,2002,224(1):258-264.
  • 8NAMIMOTO T,YAMASHITA Y,SUMI S,et al.Focal liver masses:characterization with diffusion-weighted echo-planar MR imaging[J].Radiology,1997,204 (3):739-744.
  • 9CHAN J H,TSUI E Y,LUK S H,et al.Diffusion-weighted MR imaging of the liver:distinguishing hepatic abscess from cystic or necrotic tumor[J].Abdom Imaging,2001,26 (2):161-165.
  • 10KAMEL I R,BLUEMKE D A,RAMSEY D,et al.Role of diffusion-weighted imaging in estimating tumor necrosis after chemoembolization of hepatocellular carcinoma[J].AJR,2003,181(3):708-710.

共引文献44

同被引文献39

引证文献4

二级引证文献10

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部