胸腺肽对重症毛细支气管炎免疫功能的影响

Effects of Thymosin on Immunologic Function of Patients with Severe Bronchiolitis

目的观察胸腺肽对重症毛细支气管炎T细胞亚类(CD3、CD4、CD8、CD4/CD8)及免疫球蛋白值(IgG、IgA、IgE、IgM)的影响。方法选择2008年10月-2010年12月莱钢医院住院重症毛细支气管炎患儿62例,随机分为两组。治疗组32例,在常规抗感染及对症治疗基础上加用胸腺肽治疗;对照组30例,常规治疗,观察两组患儿临床症状、体征消失时间、住院天数及治疗前、后血T细胞亚类(CD3、CD4、CD8、CD4/CD8)、免疫球蛋白(IgG、IgA、IgE、IgM)的变化。结果治疗组治疗后喘憋减轻、咳嗽、啰音消失时间明显缩短,住院天数明显减少,治疗前后血T细胞亚类(CD3、CD4、CD8、CD4/CD8)、免疫球蛋白(IgG、IgE)差异有统计学意义。治疗组疗效优于对照组(P<0.01)。结论胸腺肽可使患儿免疫功能增强,对重症毛细支气管炎的细胞免疫和体液免疫都有增强和调节作用,治疗前后差异有统计学意义。

Objective To observe the effect of thymosin on T cell subtypes（CD3,CD4,CD8,CD4/CD8） and immunoglobulin levels（IgG,IgA,IgE,IgM） in patients with severe bronchiolitis.Methods Sixty-two children with severe bronchiolitis were assigned into the treatment group（32 cases） and control group（30 cases）.The control group received the conventional treatment,while the treatment group received the thymosin based on the conventional anti-infection and symptomatic treatment.The clinical symptoms,blood T lymphocyte type（CD3,CD4,CD8,CD4/CD8）,immunoglobulin levels（IgG,IgA,IgE,IgM） changes were observed before and after the treatments.Results As compared with the control group,the duration of paroxysmal wheezy cough,dyspnea and pulmonary rales was significantly shorter in the treatment group.There were significantly different in the blood T cells sub-categories（CD3,CD4,CD8,CD4/CD8） and the immunoglobulin levels（IgG,IgE） between the two groups（P0.01）.Conclusion Thymosin can improve the immune function of children with severe bronchiolitis by enhancing and regulating the cellular immunity and humoral immune.