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FGF-1、MAPK-1在肾母细胞瘤中的表达及其意义 被引量：3

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摘要 目的肾母细胞瘤是婴幼儿泌尿系统最常见的恶性肿瘤,酸性成纤维生长因子-1(FGF-1)和丝裂原活化蛋白激酶(MAPK-1)均为肿瘤发生、发展、侵袭过程中重要的分子。本研究旨在探究肾母细胞瘤组织中FGF-1、MAPK-1蛋白的表达,初步研究其在肾母细胞瘤发病中的作用,寻找新的生物治疗的靶位点。方法收集手术切除的30例肾母细胞瘤和10例癌旁2 cm肾组织,常规固定后石蜡包埋制成腊块,制备组织芯片,采用免疫组织化学二步法检测组织芯片中FGF-1和MAPK-1的表达,结果进行χ2检验,以P<0.05为差异有统计学意义。结果 FGF-1和MAPK-1在癌旁组织中均呈弱阳性表达,在肾母细胞瘤中均呈强阳性表达,阳性率分别为63.3%和96.7%,差异具有统计学意义(P<0.05)。结论肾母细胞瘤中FGF-1及MAPK-1与癌旁对照组织相比表达明显上调,可能参与了肿瘤的发病过程。
作者 刘敏 吴秀贞
机构地区 山东省临朐县人民医院病理科
出处 《中华全科医学》 2011年第11期1754-1755,共2页 Chinese Journal of General Practice
关键词 肾母细胞瘤 FGF-1 MAPK-1 免疫组织化学
分类号 R737.11 [医药卫生—肿瘤] R730.43 [医药卫生—肿瘤]
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参考文献10

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共引文献8

同被引文献36

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中华全科医学
2011年 第11期

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