Bruker maXis系列超高分辨飞行时间质谱的性能特点和应用

Advantages and Applications of Bruker maXis series Ultra High Resolution Time of Flight Mass Spectrometry

2011年3月,Bruker公司在亚特兰大举办的Pittcon展会上推出了新型超高分辨飞行时间质谱产品(UHR-TOF)maXis 4G。这是一次非常大的突破,其分辨率达到了60,000(FWHM),质量准确度小于600 ppb。在2011的美国质谱协会年会上(ASMS),Bruker公司又推出了高性价比的maXis Impact,其分辨率达40,000(FWHM),质量准确度小于1ppm,每秒可以获得50张全谱,动态范围达4个数量级,完全可以满足超高效液相色谱快速分析的要求,实现了真正意义上的发现、鉴定和定量分析于一体,是实验室进行高通量分析的最佳选择。Bruker maXis系列质谱,实现了全范围的高分辨和高灵敏度,满足了用户对质谱同时准确定性和定量的需求,可广泛应用与化合物的表征和定性、痕量多目标物质的快速筛查和定量以及代谢组学、蛋白组学等研究。本文结合典型的应用实例,着重介绍maXis系列质谱的主要性能特点和应用。

In March,Bruker introduced the revolutionary maXis 4G system at Pittcon 2011 in Atlantic.maXis 4G sets entirely new performance heights with record-breaking 60,000 full-sensitivity resolution（FSR） and 600 parts-per-billion（ppb） mass accuracy.At ASMS,June 2011,Bruker announced a robust,affordable instrument maXis impact with uncompromised UHR-QqTOF performance.Delivering 40,000 FSR,1 ppm mass accuracy and more than four orders of magnitude dynamic range while acquiring at up to 50 full spectra per second,the maXis impact is the instrument of choice for high-throughput test laboratories,many of which are already equipped with UHPLC separations to raise throughput.The simultaneous combination of attributes is ideal for many discovery,development,screening and drug metabolism applications which often require both the identification and quantitation of sample components that vary widely in both structure and concentration.maXis impact is a powerful tool for proteomics and metabolomics studies.Here we describe the performance features of maXis series with several typical applications.