萸连缓释片胃内滞留时间考察

目的考察萸连缓释片胃内的滞留时间。方法通过高效液相色谱(HPLC)法测定胃内盐酸小檗碱的残留量,以确定萸连缓释片在体内的滞留时间。结果盐酸小檗碱进样量在2.681 5～18.769μg·ml-1浓度范围内与峰面积呈良好的线性关系(r=0.999 8,n=7),12 h时间段内萸连缓释片在胃内的含量分别为0.106,0.086,0.076,0.066,0.030,0.027,0.026 mg·ml-1。结论萸连缓释片在家兔胃内停留时间约为12 h。