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石斛中联苄类化合物抗血管新生活性研究 被引量：11

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摘要 目的观察石斛中联苄类化合物对生长因子诱导人脐静脉内皮细胞(HUVEC)增殖的影响,探讨其构效关系。方法 MTT法检测联苄类化合物对HUVEC静息期和生长因子刺激期增殖的影响。结果联苄类化合物抑制血管内皮生长因子诱导HUVEC增殖的活性依次如下:erian in,moscatilin>DC-18>gigantol>batatsin Ⅲ;抑制碱性成纤维细胞生长因子诱导HUVEC增殖的活性依次如下:erian in,moscatilin>gigantol>DC-18>batatsin Ⅲ;tristin对HUVEC静息期和生长因子刺激的增殖无影响。结论联苄类化合物的母核可能是抗血管新生作用的药效团。
作者 沈凯凯 徐蓓 王磊 杨莉 季莉莉
机构地区 上海中医药大学中药研究所.中药标准化教育部重点实验室 中国药科大学 上海中药标准化研究中心
出处 《时珍国医国药》 CAS CSCD 北大核心 2011年第4期919-921,共3页 Lishizhen Medicine and Materia Medica Research
基金 上海市基础研究重点项目(No.08JC1418500)
关键词 石斛 联苄类化合物 抗血管新生
分类号 R962 [医药卫生—药理学]
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参考文献12

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共引文献138

同被引文献178

引证文献11

二级引证文献45

时珍国医国药
2011年 第4期

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