盐酸哌罗匹隆治疗精神分裂症的临床疗效观察

目的验证盐酸哌罗匹隆治疗精神分裂症的疗效及安全性。方法将50例精神分裂症患者随机分配到盐酸哌罗匹隆组25例和阿立哌唑组25例进行为期8周的随机双盲对照研究,采用阳性和阴性症状量表(PANSS)和治疗中出现的症状量表(TESS)评定疗效,用副反应记录表评价副反应。结果治疗8周后两组患者PANSS总分及各因子分,均较治疗前明显下降。结论盐酸哌罗匹隆治疗精神分裂症的疗效与阿立哌唑相当,对精神分裂症患者的阳性症状,阴性症状等精神病性症状均有效,不良反应少。

Objective Perospirone Hydrochloride Tablets belonging to atypical antipsychotic drug, to observe perospirone treat schizophrenia efficacy and side effects, we made Aripiprazole Tablets randomized, double -blind control study. Methods Choose our hospital schizophrenia patients were retrospectively 50 cases into groups, include Perospirone groups and Aripiprazole groups every 25 cases. Using random double - blind simulation method, observe the treatment period of 8 weeks. Perospirone Hydrochloride Tablets dose 12 -48mg/d, morning, noon evening three times a day oral, Aripiprazole Tablets dose 10 -30mg/d, morning oral. Adopts PANSS therapeutic evaluation, respectively the 2, 4, 6, 8 weeks in treatment evaluation. With PANSS reduction rate evaluate the efficacy, reduction rate ≥80% was recovery, ≥50% - 〈 80% marked improvement, ≥30% -50% improvement , 〈30% ineffectiveness and ≥50% effective work. Results Our treatment results show that, Perospirone Hydrochloride Tablets of schizophrenics of positive and negative symptoms and depression, anxiety, cognitive function and so on to have obvious curative effect, its safety and tolerability can compare with Aripiprazole Tablets or better than Aripiprazole Tablets. Perospirone Hydrochloride Tablets appear low extrapyramidal adverse reaction, what is a schizophrenia long- term treatment new choice. Conclusions Perospirone groups appear low adverse reaction, it is concerned with it has serotonin （5 - HT） and dopamine D2 receptor antagonist role. Perospirone Hydrochloride Tablets have high affinity binding to 5 - HT and dopamine D2 receptor. Through the antagonism 5 - HT and D2 receptors produces antipsychotic role, to the behavior caused by the dopamine and serotonin system is very effective, causeing low extrapyramidal adverse reaction, for prolactin influence also lighter.