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Tim基因家族与T辅助细胞免疫反应 被引量：1

Tim family and Th immune response
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摘要 Th参与的免疫应答在许多疾病的发生发展中起重要作用，随着研究的深入，其新的调控机制不断被发现，Tim基因家族是新近发现的Th免疫应答中的重要调控因子，它们参与了许多Th免疫反应相关疾病的发病，了解Tim与Th免疫反应关系很有必要。 Th immune response plays an important role in the pathogenesis of many diseases. New reg- ulatory mechanism related with Th immune response has been found. Tim a newly discovered gene family,is an important regulatory factor in Th immune response. This paper focuses on the relation between Tim and Th im- mune response and the corresponding research progress made in recent years.
作者 钟玫君 谢勇
机构地区 南昌大学第一附属医院消化研究所
出处 《国际免疫学杂志》 CAS 北大核心 2011年第6期337-340,共4页 International Journal of Immunology
基金 国家自然科学基金资助项目（81160056）
关键词 TIM T辅助细胞 T-cell immunoglobulin and mucin-domain-containing molecule T helper cells
分类号 R3 [医药卫生—基础医学]
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参考文献34

  • 1Kuchroo VK, Umetsu DT, DeKruyff RH, et al. The TIM gene family: emerging roles in immunity and disease. Nat Rev hnmu- nol, 2003, 3(6) :454462.
  • 2McIntire JJ, Umetsu SE, Akbari O, et al. Identification of Tapr (an airway hyperreactivity regulatory locus ) and the linked Tim gene family. Nat lmmunol, 2001, 2(12) :1109-1116.
  • 3Su EW, Lin JY, Kane LP. TIM-1 and TIM-3 proteins in immune regulation. Cytokine, 2008, 44(1) :9-13.
  • 4Kuchroo VK, Dardalhon V, Xiao S, et al. New roles for TIM fam- ily members in immune regulation. Nat Rev Immunol, 2008, 8 (8) :577-580,.
  • 5Yeung MY, McGrath M, Najafiafi N. The Emerging Role of the TIM Molecules in Transplantation. Am J Transplant, 2011, 10: 1600-6143.
  • 6Rodriguez-Manzanet R, DeKruyff R, Kuchroo VK, et al. The cos- timulatory role of TIM molecules. Immunological Rev, 2009, 229 ( 1 ) :259-270.
  • 7Umetsu SE, Lee WL, Mclntire JJ, et al. TIM-1 induces T cell ac- tivation and inhibits the development of peripheral tolerance. Nat Immunol, 2005, 6(5) :447-454.
  • 8Mariat C, Sanchez-Fueyo A, Alexopoulos SP, et al. Regulation of T cell dependent immune responses by TIM family members. Phi- los Trans R Soc Lond B Biol Sci, 2005, 360( 1461 ) :1681-1685.
  • 9Chen q'T, Li L, Chung DH, et al. TIM-2 is expressed on B cells and in liver and kidney and is a receptor for H-ferritin endocytosis. J Exp Med, 2005, 202(7) :955-965.
  • 10Chakravarti S, Sabatos CA, Xiao S, et al. Tim-2 regulates T helper type 2 responses and autoimmunity. J Exp Med, 2005, 202 ( 3 ) :437-444.

同被引文献13

  • 1Wiercinski R,Zoch-Zwierz W,Wasile Nska A,et al.Lymphocyte Sub-populations of peripheral blood in children with Schonlein-Henoch Pur-pura and IgA nephropathy [J].Pol Merkuriusz Lek,2001,10(58):244-246.
  • 2Monney L,Sabatos CA,Gaglia JL,et al.Thl-specific cell surface pro-tein Tim-3 regulates macrophage activation and severity of an autoimmune disease[J].Nature,2002,415(6871):536-541.
  • 3Meyers JH,Chakravarti S,Schlesinger D,et al.TIM-4 is the ligand for TIM-1,and the TIM-1/TIM4 interaction regulates T cell proliferation [J].Nature immunology,2005,6(5):455-464.
  • 4De Souza A J,Oriss TB,O'Malley K.I,et al.T cell Ig and mucin 1(TIM-1)is expressed on in vivo-activated T cells and provides a cos-timulatory signal for T cell activation [J].Proceedings of the National Academy of Sciences of the United States of America,2005,102(47):17113-17118.
  • 5Xu G,Cheng L,Lu L,et al.Expression of T cell immunoglobulin and mucin domain containing molecule-1(TIM-1)is increased in a mouse model of asthma and relationship to GATA-3 [J].Life sciences,2008,82(11):663-669.
  • 6Encinas JA,Janssen EM,Weiner DB,et al.Anti-T cell Ig and mucin domain-containing protein 1 antibody decreases TH2 airway inflammation in a mouse model of asthma[J].Journal of allergy and clinical im-munology,2005,116(6):1343-1349.
  • 7Anderson AC,Lord GM,Dardalhon V,et al.T-bet,a Th1 transcrip-tion factor regulates the expression of Tim-3 [J].Eur J Immunol,2010,40(3):859-866.
  • 8Mi Jin Lee,Min-Yeong Woo,Yong-Joon Chwae,et al.Down-regulation of interleukin-2 production by CD4 + T cells expressing TIM-3 through suppression of NFAT dephosphorylation and AP-1 transcription [J].Immunobiology,2012,217(10):986-995.
  • 9Feng W,Jie X,Yalong L,et al.Tim-3 ligand galectin-9 reduces IL-17 level and accelerates Klebsiella pneumoniae infection [J].Cellular Immunology,2011,269(1):22-28.
  • 10Beebe AM,Cua DJ,de Waal MR.The role of interleukin-10 in auto-immune disease:systemic lupus erythematosus(SLE)and multiple sclerosis(MS)[J].Cytokine & growth factor reviews,2002,13(4-5):403.

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国际免疫学杂志
2011年 第6期

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