疟疾免疫记忆的研究进展

Research development of malaria immune memory

疟疾与艾滋病、结核被世界卫生组织列为对人类健康威胁最为严重的三大传染性疾病。据世界卫生组织2010年报道，全球近33亿人受到疟疾威胁，每年约有2．5亿人感染疟疾，其中有100万死亡病例。疟疾防治目前面临最大的挑战是宿主不能建立对疟原虫的长期免疫记忆。适应性T细胞和B细胞在免疫记忆中发挥关键作用，同时固有免疫细胞亦参与免疫记忆的形成，充分认识其在疟疾免疫记忆中的特点对确立疟疾的防治策略具有重要指导意义。

Malaria, one of the oldest human infectious diseases, along with AIDS and tuberculosis is i- dentified by WHO as three most severe diseases that threaten human health. According to the WHO report of 2010, nearly 330 million people are affected by malaria worldwide and about 250 million case of malaria led to million death. The biggest challenge for malaria protection and treatment is that host can not build long immune memory to the parasite. Adaptive T cell and B cell immunity play important roles in malaria immune memory. Therefore,a full understanding of malaria immune memory has instructive significance for the development of strategies for malaria protection and treatment.