中药海粉基原动物的抗肿瘤活性成分研究进展

Research progress of antitumor components from original animals of traditional Chinese medicine powder of Notarchus

对中药海粉的基原动物(海兔科动物)的抗肿瘤活性成分的结构和活性进行了系统的归纳。结果表明,分布于中国海区的海兔科6属23种动物中,已有11种有关于化学成分的报道,从其中7种动物中已发现85个以上的抗肿瘤活性成分。

Powder of Notarchus is a traditional Chinese medicine originated from the eggs of various sea hares species of family Aplysiidae Lamarck, especially Notarchus leachii cirrosus, Aplysia kurodai and A. pulmonica. It has been used for clinical treatment of cancer and cancer-like diseases in China since the Ming dynasty. Isolation and identification of numerous cytotoxic ingredients from sea hares organisms were reported. Bioactive components of sea hares in China sea including 23 species from six genera of the Aplysiidae were reviewed in this paper. Approximately 300 molecules were identified in 11 species. More than 85 compounds extracted from 7 species were confirmed to have antitumor activity, which indicated that powder of Notarehus would have potential in developing new antineoplastic agents.