重复经颅磁刺激(rTMS)提高睡眠质量的研究

Research on Repetitive Transcranial Magnetic for Improving Sleep Quality

目的:探讨重复经颅磁刺激(rTMS)改善睡眠的效果,为使用rTMS提高运动员的睡眠质量提供理论基础。方法:采用被试内设计,在被试脑干的中缝核区域分别施加假刺激(S)、无刺激(N)和磁刺激(T),比较刺激后主观感觉、生理及行为的变化。结果:在被试脑干的中缝核区域施加1 Hz,80%RMT,1 500次rTMS(持续10 s间隔2 s)后,被试的自评睡眠质量提高,状态焦虑降低;呼吸曲线的波动减少、呼吸频率降低,脉率降低,心率变异性(HRV)的相邻NN间期差值的均方根(RMSSD)和相邻NN间期差值的标准差(SDSD)降低;肢体活动减少。结论:rTMS能够提高睡眠质量,rTMS刺激后呼吸、脉率以及心率变异性(HRV)的变化在一定程度上可以对其生理效果进行解释。

Objective：Investigate the effects of repetitive transcranial magnetic（rTMS） improving dormancy,for providing a theoretical foundation by using rTMS to improve athlete＇s sleep quality.Method：Using within-subject design,given sham rTMS,no rTMS and true rTMS at the brainstem raphe nuclei region on volunteers respectively,then compared the changes of subjective feeling,physiological and behavioral.Result：Given 1Hz,80%RMT-rTMS（10 seconds on 2 seconds off） of 1 500 pulse at the brainstem raphe nuclei region on volunteers,their self-assessment of sleep quality improved,state anxiety decreased,respiratory fluctuations in the curve decreased,respiratory rate decreased,pulse decreased,the difference between adjacent NN root mean square（RMSSD） and the difference between adjacent NN interval standard deviation（SDSD） of HRV decreased,and physical activity decreased too.Conclusion：rTMS can improve sleep quality,the changes of respiratory,pulse,and heart rate variability（HRV） after rTMS might partly explain its neurobiological effect.