SonoVue和Opeison对实验鼠肝癌的诊断价值及比较

Diagnostic value and comparison of hepatic cell carcinoma by contrast-enhanced ultrasound with the types of agents:SonoVue and Opeison

目的评价SonoVue和Opeison对肝硬化基础上发生的肝细胞癌的诊断价值,并比较其增强模式。方法 16只肝硬化伴发癌结节的SD大鼠随机分为2组,分别用超声造影剂SonoVue和Opeison进行超声造影,并将造影结果与病理结果对照分析,同时比较两种造影剂的灌注过程及增强模式。结果共60个结节纳入研究,其中SonoVue组34个:造影前显示26个(76.4%),造影后显示32个(94.1%);Opeison组26个:造影前显示20个(76.9%),造影后显示24个(92.3%),4个结节坏死,造影表现为无灌注。SonoVue组28个结节表现为"快进快出";Opeison组22个结节表现为"速进快出",两种超声造影剂的增强模式相似(P>0.05)。定量分析显示两组肝细胞癌的相对增强度、增强斜率与邻近肝实质比较有明显的差异(SonoVue组,t=5.126,P=0.02;Opeison组,t=5.891,P=0.01)。结论 Opeison与SonoVue均能反映肝细胞癌的血流动力学特点,克服常规二维超声的局限,提高肝硬化下肝细胞癌的确诊率,但两者的诊断效能无明显差异。

ObjectiveTo investigate diagnostic value of hepatic cell carcinoma（HCC） in background of cirrhosis with two different contrast agents and compare their different perfusion patterns.Methods Sixteen HCC SD rats were randomly classified into two groups and were scanned with SonoVue or Opeison individually.All the contrast-enhanced ultrasound images were compared with final pathological findings.The perfusion procedure and enhanced pattern of two agents were analysed.Results There were 60 nodules in this study including 34 in SonoVue group and 26 in Opeison group.The number of nodules before and after contrast-enhanced ultrasound in the groups were 26（76.4%）,32（94.1%） and 20（76.9%）,24（92.3%）,respectively.Time-intensity curve showed no difference between two groups with relative enhanced intensity and enhanced curve slope,which were obviously different from hepatic parenchyma（SonoVue group：t=5.126,P=0.02,Opeison group：t =5.891,P=0.01）.The enhanced pattern of two groups was similar（P0.05）with ＂rapid wash in and wash out＂.Conclusion Both SonoVue and Opeison can show blood perfusion of HCC,overcome limitations of routine ultrasound,and increase HCC diagnosis in the background of cirrhosis with obviously different diagnostic values.