早期乳腺癌保乳手术与改良根治术的临床研究

Clinical research of breast-conserving surgery and modified radical mastectomy in the treatment of early breast cancer

目的:探讨保乳手术与改良根治术治疗早期乳腺癌的临床效果。方法:将我院收治的96例早期乳腺癌患者随机分为两组,A组48例行保乳手术,B组48例行改良根治术,分析两组手术时间、术中出血量、住院时间及术后恢复情况。结果:A组手术时间、术中出血量及住院时间明显优于B组,分别为手术时间[(118.52±16.35)min vs(155.87±20.55)min],术中出血量[(105.26±42.15)ml vs(153.32±51.26)ml],住院时间[(10.15±2.56)d vs(14.38±3.27)d],组间差异均有高度统计学意义(t=9.85、3.55、7.06,均P<0.01);两组术后并发症发生率分别为2.08%、16.67%,差异有统计学意义(χ2=4.41,P<0.05);两组局部复发率、远处转移率、3年及5年生存率比较,差异均无统计学意义(均P>0.05)。结论:保乳手术治疗早期乳腺癌疗效满意,值得推广应用。

Objective： To study the effect of breast-conserving surgery and modified radical mastectomy in treating early breast cancer. Methods： 96 cases with early breast cancer in our hospital were randomly divided into two groups, group A of 48 cases received breast-conserving surgery, group B of 48 cases received modified radical mastectomy, and the operation time, hemorrhage in operation, the length of hospital stay and the healing condition of the two groups were compared. Results： There were significant differences about the operation time [（118.52±16.35）min vs （155.87±20.55）mini, hemorrhage in operation [（105.26±42.15）ml vs （153.32±51.26）ml] and the length of hospital stay [（10.15±2.56）d vs （14.38±3.27）d] between two groups （t=9.85, 3.55, 7.06, all P〈0.01）. There was significant differences about the rate of postoperative complications （2.08% vs 16.67%） between the two groups （χ2=4.41, P〈0.05）. There were no significant difference in the relapse rate of part, distant transfusion rate, survival rate of 3 years and 5 years between two groups （all P〉0.05）. Conclusion： The effect of breast conserving surgery in treating early breast cancer is satisfactory, so it is recommending for wide application.