银杏酮酯分散片联合丁咯地尔在中老年基底动脉供血不足性眩晕中的应用

Application of Ginkgo Ketone Ester Dispersible Tablets combined with Buflomedil in the treatment of vertigo caused by vertebrobasilar ischemia of old age

目的:研究银杏酮酯分散片联合丁咯地尔治疗椎基底动脉供血不足性眩晕的效果与应用价值。方法:选择2009年11月～2011年4月于我院经彩色经颅多普勒超声确诊的椎-基底动脉系统短暂性脑缺血所致眩晕患者76例,将其随机分为治疗组和对照组,每组各38例。在常规治疗基础上,治疗组每日给予丁咯地尔0.2 g静注及银杏酮酯分散片1片口服,对照组每日给予倍他司汀片1片口服,两组疗程均为2周。观察两组患者临床体征、脑血流图、血液流变学指标、不良反应情况。结果:两组患者治疗后,治疗组总有效率(86.8%)显著高于对照组(60.5%),差异有统计学意义(P<0.05);治疗组的血液流变情况较对照组有明显改善,差异有统计学意义(均P<0.05);治疗组不良反应发生率为7.9%(3/38)优于对照组(10.5%,4/38)。结论:银杏酮酯分散片联合丁咯地尔应用于椎-基底动脉系统短暂性脑缺血所致眩晕治疗,具有疗效显著、稳定、安全、耐受性佳等优势,值得临床推广。

Objective： To study the clinical and application value of Ginkgo Ketone Ester Dispersible Tablets combined with Buflomedil in the treatment of vertigo caused by vertebrobasilar ischemia of old age. Methods： 76 eases of vertigo patients who were diagnosed with vertebral-basilar artery transient isehemic attack by TCD were divided into treatment group and control group, each of 38 cases. On the basis of conventional treatment, Ginkgo Ketone Ester Dispersible Tablets combined with Buflomedil were given to the treatment group and Betahistine was given to the control group. Clinical signs, rheoencephalogram, hemorheology indicators, adverse reactions of the two groups were analyzed. Results： After treatment, the total efficacy of treatment group （86.8%） was significantly better than that of the control group （60.5%） （P〈0.05）. The hemorhe- ology indicators of the treatment group were significantly better than those of the control group （all P〈0.05）. The incidence of adverse events of the treatment group （7.9%, 3/38） was significantly lower than that of the control group （10.5%, 7/38）. Conclusion： Application of Ginkgo Ketone Ester Dispersible Tablets combined with Buflomedil in the treatment of vertigo caused by vertebral-basilar artery transient ischemic attack shows steady and high efficacy, safety and good tolerability, which deserves clinical promotion.