产前超声检测胎儿眼部异常的价值

Diagnostic value of prenatal ultrasonography in detection the fetal eye abnormalities

目的探讨产前超声诊断胎儿眼部结构畸形的应用价值。方法应用二维超声对3400例胎儿眼部进行检查,结合声像图特征及引产后尸解结果对眼部异常病例进行分类诊断。结果 3400例胎儿中检出眼部结构异常20例,其中小眼畸形2例,眼距过窄及独眼6例(均合并全前脑),无眼畸形5例(双侧无眼2例,单侧无眼3例),原始玻璃体残留组织增生症(PHPV)1例,眼距过宽6例(4例合并多发畸形,1例合并微小畸形,1例为正中面裂综合征);经引产后证实产前超声诊断眼部异常正确15例,5例失随访。结论超声能直观显示胎儿眼部结构,在胎儿眼部畸形的检出及分类诊断方面有重要作用。

Objective To evaluate the value of prenatal ultrasonography in detection the fetal eye abnormalities. Methods Prenatal ultrasonography was performed in 3400 fetuses, 20 cases of fetal eye abnormalities were found. The fetal eye abnormalities were classified according to the sonographic characteristics and autopsy results. Results Among the 20 cases of fetal eye abnormalities, 2 microphthalmia, 6 ocular hypotelofism and cyclopia all combined with holoprosencephaly, 5 anophthalmos （ including 2 bilateral anophthalmos and 3 unilateral anophthalmia）, 1 persistent hyperplastic primary vitreous, 6 ocular hypertelorism （including 4 cases concomitant multiple abnormalities, 1 case of minor anomaly and 1 case of median cleft face syndrome ）. Fifteen cases were determined after termination of pregnancy and 5 cases missed following up. Conclusion Ultrasonography can directly display the fetal eye structures, and play an important role in detecting and diagnosing for type of fetal eye abnormalities.