散发性t(7;14)染色体易位10例分析

SPORADIC 7;14 TRANSLOCATION——ANANALYSIS OF TEN CASES

在125例外周血淋巴细胞G显带染色体检查中发现10例散发性t(7;14)易位。其中7例均发现于滋养细胞瘤患者夫妇中,频率高达7/47(患者3/30,患者丈夫4/17);2例为年轻的初孕妇。在22例卵巢瘤和14例其他妇科肿瘤患者中仅1例,而在22例妻子生育史正常的男性中未发现1例。

Ten cases of sporadic 7;14 transloca tion were detected in the G-banded chromosomes of peripheral blood from 125 individuals with various medical conditions. Seven out of the ten were patients with trophoblastic disease or their husbands with a frequency of occurrence as high as 7/47(3/30 for the patients and 4/17 for the husbands). No one was found in 22 adult males (14 healthy men and 8 with liver cancer) whose wives had had normal obstetric history. Only one case was found in 36 patients with either ovarian or other gynecologic tumors. The rest two cases of sporadic 7;14 translocation were detected in 13 normal gravidas. Both of them were rather young, and the authers suggested their future pregnancies be closely attended.