卵巢癌宫颈癌患者外周血染色体畸变和脆性部位的观察

OBSERVATION ON CHROMOSOME ABERRATION AND FRAGILE SITE OF PERIPHERAL LYMPHOCYTES OF PATIENTS WITH OVARIAN CANCER AND CANCER OF CERVIX UTERI

作者采用低叶酸的培养条件,对20例卵巢癌,宫颈癌和10例正常人淋巴细胞染色体畸变及脆性部位进行研究。结果表明,两种肿瘤患者的染色体畸变率和脆性部位检出率明显高于正常对照组。特别是卵巢癌患者普通型脆性位点C-fra3p14的表达与宫颈癌及正常人之间均有显著性差异,这可能与卵巢癌的特异性染色体重排del(3)(p21-13)有关。

Chromosome aberration rates (CAR) and fragile site (FS) were examined in 20 patients with ovarian, cancer and cancer of cervix uteri and in 10 health in CAR and FS women. There was a significant difference between the patients and the controls in CAR and FS. The expression frequency of c-fra3p14 observed in patients with ovarian cancer was significantly different from that of patients with cervix uteri and the controls. This result suggested the correlation between this site and cancer breakpoint at band 3p14.