SB203580对SAP大鼠胰腺组织MPO、TNF-α、IL-6和IL-8表达的影响被引量：1

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摘要目的观察p38丝裂原蛋白(p38MAPK)信号传导通路阻断剂SB203580对急性重症胰腺炎(SAP)大鼠胰腺组织髓过氧化物酶(MPO)及促炎因子TNF-α、IL-6和IL-8表达的影响。方法 46只健康雄性SD大鼠,随机分为观察组22只和SAP组24只。采用3.5%牛磺胆酸钠溶液胰胆管注射法制作SAP动物模型。观察组大鼠制模前半小时股静脉注射SB203580。造模后0.5、6、24 h取两组大鼠胰腺组织,用紫外分光光度法检测MPO活性,用放射免疫法检测TNF-α、IL-6和IL-8。结果造模后6、24 h观察组大鼠胰腺组织中MPO、TNF-α、IL-6、IL-8均低于SAP组(P均<0.05)。结论 SB203580可以降低大鼠胰腺组织中MPO、TNF-α、IL-6、IL-8的表达。

作者方巍孙晓霞李蕾

机构地区青岛大学医学院附属医院

出处《山东医药》 CAS 北大核心 2011年第38期28-29,共2页 Shandong Medical Journal

基金山东省医药卫生科技发展计划青年基金资助项目(2009QW002)

关键词胰腺炎 p38丝裂原蛋白激酶髓过氧化物酶肿瘤坏死因子白细胞介素大鼠

分类号 R657.5 [医药卫生—外科学]

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