54例急性非淋巴细胞白血病的细胞遗传学研究

CYTOGENETIC STUDIES IN 54 PATIENTS WITH ACUTE NONLYMPHOCYTIC LEUKEMIA

作者采用骨髓细胞培养,G带分析法,报告了54例急性非淋巴细胞白血病患者的染色体核型。认定t(8;16)(p11;p13);t(8;21)(q22;q22);t(9;11)(p11;q23);t(15;17)(q22;q11.2);inv(16)(p13q22);为标记染色体。报道了5种以前未曾报道的染色体异常,分别为:t(X;17)(q28;q21);t(5;7)(q31;q22);der(21)t(15;21)(21pter→21q22:8q22→8q24∷15q15→15qter);der(19)t(17;19)(q21;p13);der(7),t(4;7)(q13;q13)。指出病情变化与染色体核型改变关系密切。

Cytogenetic analyses with trypsin-Giemsa banding techniques were performed on bone-marrow cells obtained from 54 patients with acute nonlymphocytic leukemia. We observed some common characterisitic chromosomal abnormalities: t(8;16);t(8;21);t(9;11);t(15;17); inv(16). We also obtained some chromosomal abnormalities that had not been reported: t(X;17);t(5;7);der(21),t(15;21);der(19);t(17;19);der(7),t(4;7). We found the presence of a continuous abnormal karyotype was an adverse prognostic sign and these patients had a lower rate of complete remission.