高育龄妇女染色体着丝粒点研究

STUDY OF CENTROMERIC DOTS IN WOMEN OF ADVANCED CHILDBEARING AGE

该文对16例高育龄妇女细胞染色体着丝粒点(Cd)作了研究,结果表明高育龄妇女的C组和G组染色体Cd消失频率均显著高于对照组,并且高育龄妇女C组、D组和G组染色体Cd消失的实际值亦显著高于预期值。作者还提出一种"Cd-NOR融合"新现象,在高育龄妇女中这一现象的发生频率显著升高。实验结果提示,高育龄妇女易于生育非整倍体患儿可能与其染色体Cd消失及其"Cd-NOR融合"频率升高相关。

The chromosomal centromeric dots (Cd)of sixteen women of advanced childbearing age were studied by Cd-banding technique. The result showed that the frequency of Cd loss in these women was signififcantly higher than that in controls. The observed numbers of Cd loss for C-, D-, G- groups chromosomes in these women increased significantly higher than the expected numbers. A new phenomenon of 'Cd-NOR fusion' was also found in D-, G- groups chromosomes. The Cd-NOR fusion increased significantly on G-group chromosomes of these women.The findigs suggest that chromosomal nondisjunction in women of advanced childbearing age may be related to the Cd loss or 'Cd-NOR fusion' of their chromosomes.