慢性阻塞性肺疾病合并肺纤维化临床分析

目的分析慢性阻塞性肺疾病合并肺纤维化的临床特点,并探讨其临床意义。方法收集诊断的26例慢性阻塞性肺疾病合并肺纤维化(PF-COPD)患者及56例慢性阻塞性肺疾病(COPD)患者的临床资料,对两组患者的临床表现、CT、血气检查结果、肺功能改变等进行回顾分析。结果 F-COPD患者在性别、发病年龄方面与COPD患者无差别。PF-COPD患者的临床表现介于慢性阻塞性肺疾病及肺间质纤维化之间,具有两种疾病并存的CT特点,PF-COPD患者出现进展较快的呼吸困难,其肺功能测定主要表现为混合型呼吸功能障碍。血气分析常为低氧血症,二氧化碳潴留有所减轻。结论 IPF与慢性阻塞性肺疾病(COPD)是不同的两种疾病,当两种疾病合并存在时,PF-COPD表现出独特的临床特点,CT、肺功能检查、血气分析为做出临床诊断提供依据。

Objeetive To explore the clinical characteristics of chronic obstructive pulmonary diseases With pulmonary interstitial fibrosis. Methods 26 COPD with pulmonary fibrosis and 56 patients with COPD were diagnosed. Clinical symptoms, CT, lung function and arterial blood-- gas were analyzed. Results There was no difference in age and gender between COPD with pulmonary fibrosis and COPD.The clinical and radiology characteristics of COPD with pulmonary fibrosis were both COPD and pulmonary fibrosis.Compared with COPD,COPD with pulmonary fibrosis had more progressive dyspnea,mixed dysfunction,but less CO2 retention. Conclusion COPD and IPF are different diseases. When they coexist in some patients, their clinical manifestations have characteristics of both diseases.