期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

收缩性心力衰竭患者血浆Apelin-12水平变化的研究

收缩性心力衰竭患者血浆Apelin-12水平变化的研究
下载PDF
导出
摘要 目的探讨收缩性心力衰竭(Systolic heart failure,SHF)患者血浆Apelin-12水平的变化及临床意义。方法选择2010年1月～2010年6月徐州市中心医院心内科住院的慢性收缩性心力衰竭患者60例(A组),选同期体检中心心功能正常者60例作为对照组(B组)。采用酶联免疫吸附法(ELIS测定血浆Apelin-12水平。结果收缩性心力衰竭患者(A组)血浆Apelin-12水平明显低于健康对照者(B组),且差异具有统计学意义(P<0.05)。结论 Apelin-APJ系统在收缩性心力衰竭病理生理发展过程中起到重要的调节作用。 Objective To explore the change and clinical value of plasma apelin-12 in systolic heart failure patients. Methods A total of 60 patients with chronic systolic heart failure from January 2010 to June 2010 at the cardiamedical department of Xuzhou Central Hospital were involved in Group A. Another 60 healthy person with normal cardiac function were selected as control group （Group B）. The levels of plasma apelin-12 were measured by enzyme linked immunoassys （ELISA） in all subjects. Results The levels of plasma apelin-12 in SHF patients（Group A） were significantly lower than those in control group（Group B） （P〈0.05）.Conclusion The levels of plasma apelin-12 were decreased in SHF patients, which showed apelin-APJ system played an important role in the pathophysiological process of systolic heart failure.
作者 娄明 宫海滨
机构地区 徐州市中心医院心内科
出处 《当代医学》 2011年第32期74-75,共2页 Contemporary Medicine
关键词 收缩性心力衰竭 APELIN-12 血浆 Systolic heart failure Apelin-12 Plasma
分类号 R541.6 [医药卫生—心血管疾病]
  • 相关文献

参考文献14

  • 1无.慢性心力衰竭诊断治疗指南[J].中华心血管病杂志,2007,35(12):1076-1095. 被引量：3691
  • 2O' Dowd BF,HeiberM,Chan A,et al.A human gene that shows identity with the gene encoding the angiotensin receptor is Iocated on chromosome11[J]. Oene, 1993,136(1/2): 355-360.
  • 3Lee DK,Cheng E,Nguyen T,et al.Oharacterization of Apelin,the ligand for the APJ receptor[J]. J Neurochem, 2000,74(1): 54-41.
  • 4Tatemoto K,Takayama K,Zou MX,et al.The novel peptide Apelin lowers blood pressure via a nitric oxide-dependent meehanism[J].RegulPept, 2001,99(2-5):87-92.
  • 5Szokodi l,Tavi P,Foldes G,et aI.Apelin,the novel endogenous ligand of the orphan receptor APJ,regulates cardiac contractility[J].Circaes,2002, 91(5).454-440.
  • 6Kasai A,Shintani N,Oda M,et aI.Apelin is a novel angiogenic factor in retinal endothelial cells[J]. Biochem Biophys FLes Commun, 2004,525(2): 595-400.
  • 7Kidoya H,Ueno #,Yamada Y,et al.Spatial and temporal role of the apelin/APJ system in the caliber size regulation of blood vessels during angiogenesis[J]. EMBO J, 2008,27(5): 522-534.
  • 8Smith CC,Mocanu MM,Bowen J,et aI.Temporal Changes in Myocardial Salvage Kinases During Reperfusion Following Ischemia:Studies Involving the Cardioprotective Adipocytokine Apelin[J].Cardiovasc Drugs Ther,2007,21(6):409-414.
  • 9Simpkin JC,Yellon DM,Davidson SM,et al.Apelin-15 and apelin-56 exhibit direct cardioprotective activity against ischemiareperfusion injury[J]. Basic P, es Cardiol , 2007,102(6). 518-528.
  • 10Chen MM,Ashley EA,Deng DX,et al.Novel role for the potent endodenous Jnotrope Apelin in human cardiac dysfunetion[J].Oirculati on, 2005, 108(12): 1432-1439.

二级参考文献47

  • 1王方正,张澍,黄德嘉,华伟,孙宝贵,沈法荣,吴书林,王建安,方全,吴立群,王景峰,王冬梅,郭涛,陈新,中华医学会心电生理和起搏分会心脏再同步治疗专家工作组.心脏再同步治疗慢性心力衰竭的建议[J].中华心律失常学杂志,2006,10(2):90-102. 被引量：90
  • 2ISHIDA J, HASHIMOTO T, HASHIMOTO Y, et al. Regulatory roles for APJ, a seven-transmembrane receptor related to angiotensin-type 1 receptor in blood pressure in vivo[J]. J Biol Chem, 2004,279:26274-26279.
  • 3TATEMOTO K, HOSOYA M, HABATA Y, et al.Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor[J]. Biothem Biophy Res commun,1998,251:471-476.
  • 4SZOKODI I, TAVI P, FOLDES G, et al. Apelin ,the novel endogenous ligand of the orphan receptor APJ, regulates cardiac contraetility [J]. Circ Res,2002, 91:434-440.
  • 5CHEN M M,ASHLEY E A,DENG D X,et al, Novel role for the potent endogenous inotrope apelin in human cardiac dysfunction[J]. Circulation, 2003, 108:1432-1439.
  • 6Colucci WS. Molecular and cellular mechanisms of myocardial failure. Am J Cardiol, 1997, 80(11A) : 15L-25L
  • 7Braunwald E,Bristow MR Congestive heart failure: fifty years of progress. Circulation, 2000, 102(20 Suppl 4) : Ⅳ14-23.
  • 8Hunt SA, Abraham WT, Chin MH, et al. ACC/AHA 2005 Guideline Update for the Diagnosis and Management of Chronic Heart Failure in the Adult: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Update the 2001 Guidelines for the Evaluation and Management of Heart Failure) : developed in collaboration with the American College of Chest Physicians and the International Society for Heart and Lung Transplantation: endorsed by the Heart Rhythm Society. Circulation, 2005, 112 (12) :e154-235.
  • 9Swedberg K, Cleland J, Dargie H, et al. Guidelines for the diagnosis and treatment of chronic heart failure: executive summary ( update 2005 ):The Task Force for the Diagnosis and Treatment of Chronic Heart Failure of the European Society of Cardiology. Eur Heart J, 2005, 26(11): 1115-1140.
  • 10Arnold JM, Liu P, Demers C, et al. Canadian Cardiovascular Society consensus conference recommendations on heart failure 2006 : diagnosis and management. Can J Cardiol, 2006, 22 (1): 23-45.

共引文献3691

当代医学
2011年 第32期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部