米非司酮联合冰水囊用于瘢痕子宫中期妊娠引产

目的观察米非司酮联合冰水囊用于瘢痕子宫中期妊娠的的安全性与有效性。方法选择妊娠16～26周有一次子宫下段横切口剖宫产史的孕妇120例,B超提示子宫瘢痕愈合良好,其中观察组60例采用米非司酮联合冰水囊引产;对照组60例采用米非司酮联合利凡诺羊膜腔内注射引产,观察两组的引产效果及安全性。结果两组临产发动时间、总时间、术后清宫率、术后病率、住院天数比较差异有统计学意义(P<0.05)。两组在引产成功率、宫颈裂伤率、子宫破裂率及产后2h阴道出血量方面差异无统计学意义(P>0.05)。结论米非司酮联合冰水囊用于愈合良好的瘢痕子宫中期妊娠引产安全有效。

Objective To evaluate the safety and efficacy of the method of mifepristone combined with ice-water bag for m id- trimester termination in women with previous Ceaserean Section. Methods 120 women with a scarred uterus who voluntarily underwent pregnancy termination of 16-26 weeks of gestation were randomly divided into 2 groups aider the evaluation of the low eruterine segment thickness by ultrasonography（the critical value≥3mm ）. The method of mifepristone with ice-water bag insertion were adopted in study group（60cases）, and mifepristone combined intra- amniotic injection of ethacridine lactate were used in control group（60cases） ,The efficacy and safety of induced labor of two groups were investigated. Results There was significant difference of the total stage of labour, time in hospital between study group and control group（P〈0.05）. There was no significant difference of the rate of labor within 72h ,complications occur ,the volume of hemorrhage within two hours in both groups （P〈0.05）. Conclusion The application of mifepristone combined with ice-water bag in mid-trimester termination of pregnancy in scarred uterus is safe and successful. It can be used as one of the methods of termination of pregnancy with previous Ceaserean Section.