莫沙比利治疗抗精神病药物引起的便秘疗效观察

目的探索莫沙比利治疗抗精神病药物引起便秘的疗效。方法服用传统的抗精神病药物而出现便秘者30例,应用口服莫沙比利治疗便秘,分别于第2周和第4周观察患者治疗情况;观察莫沙比利治疗便秘前、后接受抗精神病药物治疗的态度接和药物不良反应。结果 30例抗精神病药物引起的便秘患者用莫沙比利治疗2周的总有效率为83.33%,4周为86.67%。治疗前不愿服抗精神药物发生率46.67%,治疗后减为20.00%;治疗前要求换其他抗精神药物发生率26.67%,治疗后减为6.67%;治疗前要求给泻药发生率40.00%,治疗后减为13.33%。治疗期间未发生明显的不良反应。结论莫沙比利治疗抗精神病药物引起便秘安全有效,有助于提高精神病患者的治疗依从性。

Objective To evaluate the effect of mosapride on psychopaths with constipation cause by antipsychotics. Methods Thirty psychopaths with constipation cause by traditional antipsychotics were treated by mosapride. The treatment statuses were observed after 2 and 4 weeks. The attitude of accepting the antipsychotics treatment and the side effects were observed. Results After 2 and 4 weeks of treatment, the total efficiency was 83.33% and 86.67%; the incidence of resistance taking antipsychotics medicine was from 46.67% to 20.00%; the incidence of request change the antipsychotics was from 26.67% to 6.67%; the incidence of using cathartic was from 40.00% to 13.33%. There were no significant side effects in the treatment. Conclusion Mosapride can improve the symptom of constipation caused by antipsychotics and raise the compliances of patients treating by antipsychotics.