健康SD大鼠空腹及进食后肾动脉血流参数的变化

Changes in renal blood flow parameters of healthy SD rats after eating food

目的:对比健康SD大鼠空腹及进食后肾动脉血流参数的变化。方法:分别于空腹及进食后使用高频彩超仪测量大鼠肾动脉内径及肾主、段动脉各项血流参数,包括最大速度(Vp)、最小速度(Vd)、平均流速(Vm)以及阻力指数(RI)、搏动指数(PI)。结果:高频彩超完全可以清楚显示大鼠肾动脉并获得满意的血流频谱图。进食后肾主、段动脉的Vp、Vd及Vm均高于其空腹状态(P<0.05),RI及PI则低于其空腹状态(P<0.05);空腹或进食后同等状态下左、右肾动脉内径及肾主、段动脉上述各项血流参数均无侧别间差异(P>0.05)。结论:空腹与进食后相比较,大鼠肾动脉血流参数可发生改变,表现为进食后血流速度加快、RI及PI减低。

Objective： To observe changes in renal artery blood flow parameters in fasting SD rats after eating food.Methods： With high frequency color Doppler instrument,we measured Diameters of renal artery blood flow parameters of main renal artery（MRA）and section renal artery（SRA） in healthy SD rats before and after eating food were measured including maximum blood flow velocity（Vmax）,minimum blood flow velocity（Vmin） and mean blood flow velocity（Vm）,resistance index（RI） and pulsatility index（PI）.Results： Rats′ renal artery and spectrum could be clearly displayed under high frequency color Doppler instrument.After eating food,the Vmax,Vmin and Vm of MRA and SRA were significant higher than that in fasting rats（P〈0.05）;but RI and PI were lower in fasting rats（P〈0.05）.No significant difference was observed between parameters of left and right renal artery or between MRA and SRA（P〈0.05）.Conclusions： Renal artery blood flow velocity of healthy SD rats could accelerate while RI and PI decrease after eating food.